Handbook of Human Immunology

by Leffell, Mary S.; Donnenberg, Albert D.; Rose, Noel R.

• ISBN13: 9780849301346
• ISBN10: 0849301343
• Format: Hardcover
• Copyright: 1997-05-01
• Publisher: CRC Pr I Llc

Summary

Combining basic explanations of laboratory tests with 115 tables full of reference data and applications, the Handbook of Human Immunology provides practicing clinicians with a current, complete guide to molecular immunology. Introductory chapters overview the molecular basis of immune responses and immunological disorders, focusing on the role of cell receptors, accessory molecules, and cytokines in these processes. Emphasis is placed on immunological parameters that are clinically useful. The basic principles underlying assays of the immune system are discussed, and the book stresses the application and interpretation of immune tests.Comprehensive coverage is given to immunoglobulins and their age-dependent concentration. Cellular immunology is discussed from the perspectives of lymphocyte functional parameters, as well as through immunophenotyping of lymphocytes and other leukocytes. Both serological and molecular diagnosis of infectious diseases are reviewed.The Handbook of Human Immunology contains up-to-date information on exciting developments in immunogenetics, covering the application of T-cell receptor genes and the HLA alleles in disease associations and transplantation.

Table of Contents

Chapter 1 An Overview of the Immune System: The Molecular Basis for Immune Responses	1	(46)
Mary S. Leffell
Chapter 2 An Overview of the Immune System: Immunological Mechanisms in Immune Deficiency and Autoimmunity	47	(18)
Albert D. Donnenberg
Chapter 3 Human Immunoglobulins	65	(46)
Robert G. Hamilton
Chapter 4 Immunologic Diagnosis of Autoimmunity	111	(14)
Noel R. Rose
Chapter 5 Infectious Disease Serology	125	(28)
Kimberly L. Kane
James D. Folds
Chapter 6 Molecular Techniques Applied to Infectious Diseases	153	(80)
Preeti Pancholi
David H. Persing
Chapter 7 Cytokines in Human Immunology	233	(34)
Barbara Detrick
John J. Hooks
Chapter 8 Complement	267	(52)
Robert H. McLean
Thomas R. Welch
Chapter 9 Evaluation of Phagocytic Cell Disorders	319	(24)
Naynesh R. Kamani
Steven D. Douglas
Chapter 10 Cellular Immunology: Monitoring of Immune Therapies	343	(38)
Theresa L. Whiteside
Chapter 11 Clinical Applications of Flow Cytometry	381	(96)
Alan Winkelstein
Albert D. Donnenberg
Chapter 12 Relevance of Antibody Screening and Crossmatching in Solid Organ Transplantation	477	(44)
Andrea A. Zachary
John M. Hart
Chapter 13 DNA-Based Typing of HLA for Transplantation	521	(46)
Carolyn Katovich Hurley
Chapter 14 Methods for the Analysis of the Human T-Cell Receptor (TCR) Repertoire in Health and Disease	567	(42)
Pradip N. Akolkar
Beena Gulwani-Akolkar
Jack Silver
Index	609