Handbook of Iron Overload Disorders

by James C. Barton , Corwin Q. Edwards , Pradyumna D. Phatak , Robert S. Britton , Bruce R. Bacon

• ISBN13: 9780521873437
• ISBN10: 0521873436
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-09-06
• Publisher: Cambridge University Press

Summary

A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.

Table of Contents

Foreword

Preface

History of iron overload disorders

Normal iron absorption and metabolism

Iron toxicity

Tests for hemochromatosis and iron overload

Complications of hemochromatosis and iron overload

Insulin resistance and iron overload

Infections and immunity

Classical and atypical hfe hemochromatosis

Heterozygosity for hfe c282y

Porphyria cutanea tarda

Mitochondrial mutations as modifiers of hemochromatosis

Hemochromatosis associated with ferroportin gene (slc40a1) mutations

Hemochromatosis associated with hemojuvelin gene (hjv) mutations

Hemochromatosis associated with hepcidin gene (hamp) mutations

Hemochromatosis associated with transferrin receptor-2 gene (tfr2) mutations

Iron overload associated with ire mutation of ferritin heavy-chain gene (fth1)

Hereditary hyperferritinemia-cataract syndrome: ire mutations of ferritin light chain gene (ftl)

Iron overload in native Africans and African Americans

Hereditary atransferrinemia

Divalent metal transporter-1 (dmt1) iron overload

Iron overload associated with thalassemia syndromes

Iron overload associated with hemoglobinopathies

Iron overload associated with pyruvate kinase deficiency

Iron overload associated with congenital dyserythropoietic anemias

Hereditary sideroblastic anemias

Pearson marrow-pancreas syndrome

Acquired sideroblastic anemias

Hereditary aceruloplasminemia

Friedreich ataxia and cardiomyopathy

Pantothenate kinase (pank2)-associated neurodegeneration

Neuroferritinopathies

Gracile syndrome

Neonatal hemochromatosis

Iron overload due to excessive supplementation

Localized iron overload

Management of iron overload

Population screening for hemochromatosis

Ethical, legal, and social issues

Directions for future research

Index

Table of Contents provided by Publisher. All Rights Reserved.