Handbook of Models for Human Aging

by Conn; Benjamin; Finch; Guerin; Nelson; Olshansky; Roth; Smith

• ISBN13: 9780123693914
• ISBN10: 0123693918
• Format: Hardcover
• Copyright: 2006-02-24
• Publisher: Elsevier Science

Summary

This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. *Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations

Table of Contents

Contributors	xi
Preface	xxi
I. Introduction
Historical Development of Animal Models of Aging	1	(8)
Richard L. Sprott
Steven N. Austad
Species Selection in Comparative Studies of Aging and Antiaging Research	9	(12)
Joao Pedro de Magalhaes
Principles of Animal Use for Gerontological Research	21	(12)
Richard A. Miller
From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes	33	(12)
Rita B. Effros
Models of Systems Failure in Aging	45	(24)
Leonid A. Gavrilov
Natalia S. Gavrilova
Major Issues in Ethics of Aging Research	69	(10)
Michael D. Smith
Ethical Aspects of Research Involving Elderly Persons	79	(14)
Paul S. Mueller
C. Christopher Hook
II. General Methods
SAGE KE and Other Online Sources Related to Aging	93	(6)
Evelyn Strauss
R. John Davenport
Proteomics in Aging Research	99	(10)
Christian Schoneich
Application of High-Throughput Technologies to Aging-Related Research	109	(12)
Matt Kaeberlein
Models of Alzheimer's Disease	121	(14)
Harry LeVine III
Lary C. Walker
Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs. Normal Aging	135	(8)
Scott A. Small
Epidemiology in Aging Research	143	(10)
Hermann Brenner
Volker Arndt
Statistical Issues for Longevity Studies in Animal Models	153	(12)
Chenxi Wang
Scott W. Keith
Kevin R. Fontaine
David B. Allison
Models for the Study of Infection in Populations	165	(18)
John R. Williams
Estimation of the Rate of Production of Oxygen Radicals by Mitochondria	183	(8)
Alberto Sanz
Gustavo Barja
III. Animal Models
A. Non-mammalian Systems
Telomeres and Aging in the Yeast Model System	191	(16)
Kurt W. Runge
Longevity and Aging in Budding Yeast	207	(12)
Matt Kaeberlein
From Yeast Methuselah Genes to Evolutionary Medicine	219	(10)
Paola Fabrizio
Valter D. Longo
Strongyloides ratti: A Nematode with Extraordinary Plasticity in Aging	229	(12)
Michael P. Gardner
David Gems
Mark E. Viney
Insect Models for the Study of Aging	241	(12)
Klaus-Gunter Collatz
Drosophila Models of Aging	253	(14)
Satomi Miwa
Alan Cohen
Models of Aging in Honeybee Workers	267	(10)
Gro V. Amdam
Olav Rueppell
Ants as Naturally Long-lived Insect Models for Aging	277	(6)
Joel D. Parker
Karen M. Parker
Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster	283	(18)
Robert Arking
Annual Fish as a Genetic Model for Aging	301	(8)
Pudur Jagadeeswaran
The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease	309	(8)
Evan T. Keller
Jill M. Keller
Gavin Gillespie
Zebrafish as Aging Models	317	(22)
Shuji Kishi
Telomeres in Aging: Birds	339	(12)
Susan E. Swanberg
Mary E. Delany
Domestic and Wild Bird Models for the Study of Aging	351	(16)
Donna J. Holmes
Mary Ann Ottinger
B. Mammalian Systems
A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction	367	(12)
Isao Shimokawa
Rat Models of Age-Related Cognitive Decline	379	(14)
Jennifer L. Bizon
Michelle M. Nicolle
Aged Rodents for Biogerontology Research	393	(10)
Nancy L. Nadon
Life Extension in the Dwarf Mouse	403	(12)
Andrzej Bartke
The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology	415	(20)
P. Dwight Tapp
Christina T. Siwak
Bats as a Novel Model for Aging Research	435	(12)
Anja K. Brunet-Rossinni
Rocco E. Rossinni
Memory in the Aging Hippocampus: What Can Place Cells Tell Us?	447	(10)
Iain A. Wilson
The Rhesus Macaque as a Model of Human Aging and Age-Related Disease	457	(12)
Mary Ann Ottinger
Julie A. Mattison
Mary B. Zelinski
Julie M. Wu
Steven G. Kohama
George S. Roth
Mark A. Lane
Donald K. Ingram
Nonhuman Primates as a Models for Reproductive Aging and Human Infertility	469	(16)
Barry D. Bavister
Carol A. Brenner
IV. Comparative Models
Neurobiology of the Aging Brain	485	(22)
Carlo Bertoni-Freddari
Patrizia Fattoretti
Tiziana Casoli
Giuseppina Di Stefano
Mitochondrial DNA and Aging	507	(14)
Mikhail Alexeyev
Susan P. LeDoux
Glenn L. Wilson
Models for Apoptosis: From Newborn to Adult	521	(12)
Christiane Charriaut-Marlangue
Sylvain Renolleau
Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence	533	(20)
Jacqueline A. Maffucci
Andrea C. Gore
Models of Chaperones in Aging	553	(10)
Jens Kroll
J. O. Nehlin
Therapeutic Potential of Stem Cells in Aging-Related Diseases	563	(12)
Shannon Whirledge
Kirk C. Lo
Dolores J. Lamb
Nuclear Transfer and Cloning: Preservation or Expansion of Proliferative Lifespan?	575	(10)
Keith E. Latham
Human Models of Longevity	585	(6)
Thomas Perls
Computational Models of Mitochondrial DNA in Aging	591	(10)
David C. Samuels
Mouse Models of Accelerated Aging	601	(18)
Jan Vijg
Paul Hasty
V. Disease-States and Normal Aging
A. Disease States
Models, Definitions, and Criteria of Frailty	619	(12)
David B. Hogan
Fertility and Aging Men: An Introduction to the Male Biological Clock	631	(10)
Peter N. Schlegel
Puneet Masson
Sarah M. Lambert
Harry Fisch
Benign Prostatic Hyperplasia	641	(10)
Peter Celec
Murine Models of Infectious Diseases in the Aged	651	(10)
Kevin P. High
Studying Infection in the Elderly: Physiopathology, Clinical Symptoms and Causative Agents of Pneumonia	661	(10)
Jean-Paul Janssens
Diabetes and Aging	671	(16)
Tamas Fulop
Anis Larbi
Daniel Tessier
Andre Carpentier
Diabetes as a Model of Premature Aging	687	(10)
Arshag D. Mooradian
Frailty as a Model of Aging	697	(6)
Jeremy D. Walston
Osteoporosis and Cardiovascular Disease in the Elderly	703	(10)
Samy I. McFarlane
John Nicasio
Ranganath Muniyappa
Depression in Older Patients	713	(14)
Kiran Rabheru
The Aging Human Lung: Age-Associated Changes in Structure and Function	727	(8)
Keith C. Meyer
Iceland as a Model for Human Aging	735	(6)
Adalsteinn Gudmundsson
Palmi V. Jonsson
Behavior and Personality in the Study of Successful Aging	741	(8)
Judith Corr
Loraine Tarou
B. Health Issues Affecting the Elderly
Andropause	749	(10)
Rabih Hijazi
Glenn R. Cunningham
Aging and the Perceptual Organization of Sounds: A Change of Scene?	759	(12)
Claude Alain
Benjamin J. Dyson
Joel S. Snyder
Models of Immune Function in Aging	771	(10)
Christopher A. Jolly
Zhun Xu
Human T Cell Clones in Long-Term Culture as Models for the Impact of Chronic Antigenic Stress in Aging	781	(12)
Graham Pawelec
Erminia Mariani
Rafael Solana
Rosalyn Forsey
Anis Larbi
Simone Neri
Olga Dela Rosa
Yvonne Barnett
Jon Tolson
Tamas Fulop
Age-Related Changes in the Human Retina	793	(20)
Carlo Cavallotti
Nicola Pescosolido
Models of Age-Related Vision Problems	813	(16)
J. Fielding Hejtmancik
Mark Kantorow
Takeshi Iwata
Health, Functional and Therapeutic Implications of Obesity in Aging	829	(12)
R. Lee Kennedy
E. Y. H. Khoo
Age and Joints	841	(12)
Klaus Bobacz
Ilse-Gerlinde Sunk
Sleep Quality in the Elderly	853	(12)
Ragnar Asplund
Atherogenesis and Aging	865	(8)
Cam Patterson
Managing Menopausal Symptoms	873	(8)
Mary Ellen Rousseau
Psychological Aging: A Contextual View	881	(16)
Hans-Werner Wahl
Frieder R. Lang
Nutrients and Aging	897	(14)
Lawrence J. Whalley
C. Approaches to Treatment and Models
Methods for Studying Hearing Impairment and Auditory Problems of the Aged	911	(12)
Robert D. Frisina
D. Robert Frisina
A Model for Understanding the Pathomechanics of Osteoarthritis in Aging	923	(14)
Thomas P. Andriacchi
Annegret Mundermann
Aging and Cardiovascular Angiogenesis Models	937	(10)
Andrew Chin
Jacquelyn M. Holm
Inga J. Duignan
Jay M. Edelberg
Models for the Study of Stroke	947	(14)
Thiruma V. Arumugam
Mark P. Mattson
Werner Syndrome as a Model of Human Aging	961	(16)
Raymond J. Monnat, Jr.
Models of Sarcopenia	977	(16)
Alfred L. Fisher
Aging of Human Skin	993	(6)
Paolo U. Giacomoni
Models of Hypertension in Aging	999	(12)
Jane F. Reckelhoff
Radu Iliescu
Licy Yanes
Lourdes A. Fortepiani
Glossary	1011	(30)
Index	1041