Handbook of Mucosal Immunology

by Pearay L. Ogra; Jerry R. McGhee; Jiri Mestecky

• ISBN13: 9780125247306
• ISBN10: 0125247303
• Format: Hardcover
• Copyright: 1994-01-01
• Publisher: Academic Press, Incorporated

Summary

Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis. Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.

Table of Contents

Contributors

Preface

Acknowledgment

Introduction: An Overview of the Mucosal System

Structure and Function of Intestinal Mucosal Epithelium

Cellular and Molecular Basis for Antigen Transport in the Intestinal Epithelium

Mucosal Barrier

Innate Humoral Factors

Bacterial Adherence and Mucosal Immunity

Mucosal Immunoglobulins

Phylogenetic Aspects of Mucosal Immunoglobulins

Developmental Aspects of Mucosal Immunoglobulin Genes: Organization and Expression of IgA Heavy-Chain, Polymeric Immunoglobulin Receptor, and J-Chain Genes

Epithelial and Hepatobiliary Transport of Polymeric Immunoglobulins

Function of Mucosal Immunoglobulins

Characteristics and Functions of Mucosa-Associated Lymphoid Tissue

Peyer's Patches as Inductive Sites for IgA Commitment

Regulation of IgA B Cell Development

Diversity and Function of Antigen-Presenting Cells in Mucosal Tissues

Oral Tolerance and Regulation of Immunity to Dietary Antigens

Functional Aspects of the Peptidergic Circuit in Mucosal Immunity

The Role of B-1 Cells in Mucosal Immune Responses

Lymphocyte Homing to Mucosal Effector Sites

Cytokines in the Mucosal Immune System

Distribution and Characteristics of Mucosal Immunoglobulin-Producing Cells

T Helper Cells for Mucosal Immune Responses

Human Gastrointestinal Mucosal T Cells

Basic Aspects of Intraepithelial Lymphocyte Immunobiology

IgE-Mediated Responses in the Mucosal Immune System

Inflammation: Mast Cells

Cytokines in the Liver and Gastrointestinal Tract

Cytotoxic Lymphocytes in Mucosal Effector Sites

Mucosal Immunity to Viruses

Passive Immunization: Systemic and Mucosal

Common Mucosal Immune System and Strategies for the Development of Vaccines Effective at the Mucosal Surfaces

Antigen Delivery Systems: New Approaches to Mucosal Immunization

Mucosal Adjuvants

Monoclonal Secretory IgA for Protection of the Intestinal Mucosa against Viral and Bacterial Pathogens

Gut-Associated Lymphoid Tissue

Alpha Chain Disease and Related Lymphoproliferative Disorders

Gastritis and Peptic Ulcer

The Role of the Mucosal Immune System in Ulcerative Colitis and Crohn's Disease

Malabsorption Syndromes and Intestinal Protein Loss

Food Allergy

Intestinal Infections

Liver and Biliary Tract

Bronchial Mucosal Lymphoid Tissue

Mucosal Immune Function in Asthma

Respiratory Infections

Inhalant Allergy and Hypersensitivity Disorders

Ocular Mucosal Immunity

Mucosal Immunology of the Middle Ear and Eustachian Tube

Immunology of Diseases of the Oral Cavity

Immunobiology of the Tonsils and Adenoids

Immunological Components of Milk: Formation and Function

Immunologic Effects of Breast-Feeding on the Infant

IgA Nephropathy and Related Diseases

Mucosal Immunity in the Female and Male Reproductive Tracts

Immunologically Mediated Male and Female Reproductive Failure

Endocrine Regulation of Mucosal Immunity: Effect of Sex Hormones and Cytokines on the Afferent and Efferent Arms of the Immune System in the Female Reproductive Tract

Mucosal Immunopathophysiology of HIV Infection

Genital Tract Infection: Implications in the Prevention of Maternal and Fetal Disease

Index

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