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Imperial College of Science, Technology and Medicine, London, UK
M. Bishop
CNR-ITB, Milan, Italy
C. Cannings
University of Sheffield, UK
List of Contributors | |
Editor's Preface to the Third Edition | |
Glossary of Terms | |
Abbreviations and Acronyms | |
Genomes | |
Chromosome Maps | |
Introduction | |
Genetic Maps | |
Physical Maps | |
Radiation Hybrid Mapping | |
Other Physical Mapping Approaches | |
Gene Maps | |
Acknowledgments | |
References | |
Statistical Significance in Biological Sequence Comparison | |
Introduction | |
Statistical Significance and Biological Significance | |
Estimating Statistical Significance for Local Similarity Searches | |
Summary: Exploiting Statistical Estimates | |
Acknowledgments | |
References | |
Bayesian Methods in Biological Sequence Analysis | |
Introduction | |
Overview of the Bayesian Methodology | |
Hidden Markov Model: A General Introduction | |
Pairwise Alignment of Biological Sequences | |
Multiple Sequence Alignment | |
Finding Recurring Patterns in Biological Sequences | |
Joint Analysis of Sequence Motifs and Expression Microarrays | |
Summary | |
Acknowledgments | |
Markov Chain Monte Carlo Methods | |
References | |
Statistical Approaches in Eukaryotic Gene Prediction | |
Structural Organization and Expression of Eukaryotic Genes | |
Methods of Functional Signal Recognition | |
Linear Discriminant Analysis | |
Prediction of Donor and Acceptor Splice Junctions | |
Identification of Promoter Regions in Human DNA | |
Recognition of PolyA Sites | |
Characteristics for Recognition of 3-Processing Sites | |
Identification of Multiple Genes in Genomic Sequences | |
Discriminative and Probabilistic Approaches for Multiple Gene Prediction | |
Internal Exon Recognition | |
Recognition of Flanking Exons | |
Performance of Gene Identification Programs | |
Using Protein Similarity Information to Improve Gene Prediction | |
Genome Annotation Assessment Project (EGASP) | |
Annotation of Sequences from Genome Sequencing Projects | |
Characteristics and Computational Identification of miRNA genes | |
Prediction of microRNA Targets | |
Internet Resources for Gene Finding and Functional Site Prediction | |
Acknowledgments | |
References | |
Comparative Genomics | |
Introduction | |
Homology | |
Genomic Mutation | |
Comparative Maps | |
Gene Order and Content | |
Whole Genome Sequences | |
Conclusions and Future Research | |
Acknowledgments | |
References | |
Beyond the Genome | |
Analysis of Microarray Gene Expression Data | |
Introduction | |
Data Visualization and Quality Control | |
Error Models, Calibration and Measures of Differential Expression | |
Identification of Differentially Expressed Genes | |
Pattern Discovery | |
Conclusions | |
Acknowledgments | |
References | |
Statistical Inference for Microarray Studies | |
Introduction | |
Initial Data Processing | |
Testing the Association of Phenotype with Expression | |
Multiple Testing | |
Annotation Analysis | |
Validation Analysis | |
Study Design and Sample Size | |
Discussion Related Chapters | |
References | |
Bayesian Methods for Microarray Data | |
Introduction | |
Extracting Signal From Observed Intensi | |
Table of Contents provided by Publisher. All Rights Reserved. |
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