Handbook of Topical Antimicrobials: Industrial Applications in Consumer Products and Pharmaceuticals

by Paulson; Daryl S.

• ISBN13: 9780824707880
• ISBN10: 0824707885
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-09-19
• Publisher: CRC Press

Summary

This reference examines laboratory techniques and FDA and industry perspectives on medical, food service, and consumer product applications of antimicrobials. It offers methods to conduct investigations of effectiveness that simulate use of consumer, food, and medical antimicrobials in real-world conditions and environments, validate neutralizing systems, develop reliable and functional antimicrobial products, and prevent infection, disease, and contamination. Additional topics include the importance of customer-valued quality attributes, such as low skin irritation and ease of use, label claims, regulatory procedures, and quality control, and clinical simulation protocols.

Table of Contents

Preface	iii
Contributors	ix
Part 1 Overview	1	(70)
Introduction to Topical Antimicrobials and Their Applications	3	(16)
Daryl S. Paulson
Food and Drug Administration Perspective on Topical Antiseptic Drug Product Development	19	(30)
Albert T. Sheldon, Jr.
Healthcare Continuum: A Model for the Classification and Regulation of Topical Antimicrobial Products	49	(22)
George E. Fischler
Marc Shaffer
Rhonda D. Jones
Part II Topical Antimicrobials	71	(60)
Clinical Applications of Povidone-Iodine as a Topical Antimicrobial	77	(22)
Steven Ripa
Nancy Bruno
Robert F. Reder
Renate Casillis
Robert I. Roth
Quaternary Ammonium Compounds	99	(18)
Edward B. Walker
Chlorhexidine Gluconate	117	(6)
Daryl S. Paulson
Alcohols	123	(8)
Daryl S. Paulson
Part III Product Applications	131	(122)
Microorganisms and Disease	133	(8)
Daryl S. Paulson
Nosocomial Infection	141	(16)
Daryl S. Paulson
Postsurgery Infection	157	(10)
Daryl S. Paulson
Antimicrobial Body Washes	167	(14)
David W. Hobson
Lawton Anthony Seal
Some Aspects of Human Disease and Staphylococcus Species	181	(8)
Daryl S. Paulson
Full-Body Shower Wash: Efficacy Evaluation of a 4% Chlorhexidine Gluconate	189	(8)
Daryl S. Paulson
Surgical Preparation and Site Access: Testing's Stepchild	197	(24)
Mary Bruch
Brushless Surgical Scrubbing and Handwashing	221	(20)
David W. Hobson
Lawton Anthony Seal
Fundamental Steps in Designing a Healthcare Personnel Handwash	241	(12)
Daryl S. Paulson
Part IV Food	253	(60)
Handwashing, Gloving, and Disease Transmission by the Food Preparer	255	(16)
Daryl S. Paulson
Handwashing and Gloving for Food Protection: Examination of the Evidence	271	(20)
Eleanor J. Fendler
Michael J. Dolan
Ronald A. Williams
Handwashing and Gloving for Food Protection: Effectiveness	291	(12)
Eleanor J. Fendler
Michael J. Dolan
Ronald A. Williams
Daryl S. Paulson
A Suggested Method for Evaluating Foodhandler/Processor Handwash Formulations	303	(10)
Daryl S. Paulson
Part V Consumer Products	313	(50)
Appropriateness of the Healthcare Personnel Handwash Test in Assessing Efficacy of Consumer Handwashing Products	315	(18)
Bruce H. Keswick
Kathy F. Wiandt
Ward L. Billhimer
Development of Methods to Evaluate Efficacy of Handwashing Products for Consumers	333	(22)
Bruce H. Keswick
Kathy F. Wiandt
Ward L. Billhimer
Importance of Skin Care Attributes in Developing Topical Antimicrobials	355	(8)
Daryl S. Paulson
Part VI Testing Methods	363	(84)
A Guide for Validation of Neutralizer Systems Used in Topical Antimicrobial Efficacy Evaluations	365	(12)
Christopher M. Beausoleil
Testing Methodology of Preoperative Skin Preparation and Surgical Scrub as Over-the-Counter Drugs	377	(18)
David K. Jeng
Skin Sampling Techniques	395	(16)
Barry Michaels
The Need and Methods for Assessing the Activity of Topical Agents Against Viruses	411	(36)
Shamim A. Ansari
Syed A. Sattar
Index	447