Handbook of Tuberculosis Immunology and Cell Biology

by Kaufmann, Stefan H. E.; Britton, Warwick J.

• ISBN13: 9783527318872
• ISBN10: 3527318879
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-03-03
• Publisher: Wiley-Blackwell

Summary

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes' lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease.Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charit_ at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis.The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health.Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis.Volume 2: Immunology and Cell Biology presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials. It is co-edited by Dr. Paul van Helden, Professor of Medical Biochemistry at Stellenbosch University, South Africa, Director of Laboratory Research for the Desmond Tutu Tuberculosis Centre and former President of the South African Society of Biochemistry and Molecular Biology.

Author Biography

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize.

Warwick Britton is Professor of Medicine at the University of Sydney, Australia. He serves as Chairman of the State Committee for the Australian Society of Clinical Immunology and Allergy.

Table of Contents

Immunity to M. tuberculosis and BCG: Introduction Recognition Receptors and Phagocytosis for M. tuberculosis

Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis

Dendritic Cells and Antigen Presentation Killing Mechanisms of the Host Against M. tuberculosis

Manipulation of the Macrophage Response Conventional T Cells and their Antigenic Repertoire Unconventional

T Cells Cytokines in Tuberculosis Antibodies in Tuberculosis Pathology Maintenance of Latent Infection with Correlates of Protective

Immunity Genetics of Resistance (mouse and man) HIV/TB Interactions Novel Vaccination Strategies Against Tuberculosis Experimental

Animal Models of Tuberculosis

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