Handbook of Tuberculosis, 3 Volume Set

by Kaufmann, Stefan H. E.; van Helden, Paul; Rubin, Eric; Britton, Warwick J.

• ISBN13: 9783527316830
• ISBN10: 3527316833
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-03-17
• Publisher: Wiley-Blackwell

Summary

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes' lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease.Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charit_ at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis.The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health.Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis.Volume 2: Immunology and Cell Biology presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials. It is co-edited by Dr. Paul van Helden, Professor of Medical Biochemistry at Stellenbosch University, South Africa, Director of Laboratory Research for the Desmond Tutu Tuberculosis Centre and former President of the South African Society of Biochemistry and Molecular Biology.

Author Biography

Prof. Dr. Stefan H.E. Kaufmann is Founding Director of the Max Planck Institute for Infection Biology, Berlin. He has published more than 600 scientific articles and is member of numerous scientific societies and committees e.g. current President of the European Federation of Immunological Societies, and Chair of the Immunology division of the American Society of Microbiology. He has won numerous prestigious awards including the Scientific Prize of Smith Kline Beecham and the Pettenkofer Prize.

Paul van Helden is Professor of Medical Biochemistry at Stellenbosch University, South Africa. He is Director of Laboratory Research for the Desmond Tutu TB Centre. He is a past president of the SA Society of Biochemistry and Molecular Biology, and has received the Gold medal of this society.

Eric Rubin is Professor of Immunology and Infectious Diseases at the Harvard School of Public Health. He carried out both his MD and PhD work at Tufts University.

Warwick Britton is Professor of Medicine at the University of Sydney, Australia. He serves as Chairman of the State Committee for the Australian Society of Clinical Immunology and Allergy.

Table of Contents

Molecular Biology and Biochemistry

Tuberculosis - Molecular Genetics and Biochemistry: Introduction Biochemistry of the Cell Wall

Glycolipids and Polyketides of M. tuberculosis Physiology of M. tuberculosis Nutrient Transport Iron Uptake by M. tuberculosis Protein

Transport PE and PPE Gene Family Members in M. tuberculosis Virulence/Persistence Mechanisms of M. tuberculosis Genomics

Transcriptomics and Transcriptional Regulation Proteomics of M. tuberculosis Structure

Molecular Mechanisms of Dormancy and Resuscitation M. tuberculosis in the Phagosome

Molecular Mechanisms of Drug Resistance of M. tuberculosis Experimental Genetics of M. tuberculosis

Molecular Evolution of Mycobacteria

Immunology and Cell Biology

Introduction: Immunity to M. tuberculosis and BCG Recognition Receptors and Phagocytosis for M. tuberculosis

Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis

Dendritic Cells and Antigen Presentation Killing Mechanisms of the Host

Against M. tuberculosis Manipulation of the Macrophage Response Conventional T Cells and their Antigenic Repertoire

Unconventional T Cells Cytokines in Tuberculosis Antibodies in Tuberculosis Pathology

Maintenance of Latent Infection with Correlates of Protective Immunity Genetics of Resistance (mouse and man)

HIV/TB Interactions Novel Vaccination Strategies Against Tuberculosis Experimental

Animal Models of Tuberculosis

Clinics Diagnostics Therapy and Epidemiology

Clinics Diagnostics Therapy Epidemiology: Introduction Global Epidemiology of Tuberculosis Surveillance Studies and Interpretation

Molecular Epidemiology of M. tuberculosis Diagnosis of M. tuberculosis: Clinical

Clinical Disease (with and without HIV) Management of Tuberculosis Patients Chemotherapy

New Drugs and Clinical Drug Trials Latency Drug Resistance in Clinical Context Novel Drug

Treatment Strategies - Co-infections Modeling BCG Vaccination

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