Harper's Illustrated Biochemistry

by Murray, Robert; Granner, Daryl K.; Rodwell, Victor W.; Botham, Kathleen

• ISBN13: 9780071461979
• ISBN10: 0071461973
• Edition: 27th
• Format: Paperback
• Copyright: 2006-06-13
• Publisher: McGraw-Hill Medical

Summary

Harper's Illustrated Biochemistry offers concise, up-to-date, and authoritative coverage of the principles of biochemistry and molecular biology as they relate to medicine. Revised for clarity, with new streamlined organization, new figures, and new online image collection Reflects major advances in biochemistry that are important to medicine Includes new chapters on amino acids and peptides, primary structure of proteins, and the Human Genome Project Presents new and expanded coverage of the mechanisms of action of enzymes, receptors involved in lipoprotein metabolism and reverse cholesterol transport, RNA synthesis, gene regulation, molecular mechanisms of hormone action, protein life cycle, and pharmacogenomics Provides clinical correlations and chapter summaries Features more than 500 clear, descriptive illustrations

Author Biography

Robert Murray, MD - Professor of Biochemistry, University of Toronto

Daryl Granner, MD - Professor of Molecular Physiology and Biophysics, Vanderbilt University

David Bender, PhD - Dept. of Biochemistry and Molecular Biology, University College of London

Kathleen Botham, PhD - Dept. of Veterinary Basic Sciences, The Royal Veterinary College

Victor Rodwell, PhD - Professor of Biochemistry, Purdue University

Table of Contents

Biochemistry & medicine	p. 1
Water & pH	p. 5
Amino acids & peptides	p. 14
Proteins : determination of primary structure	p. 21
Proteins : higher orders of structure	p. 30
Proteins : myoglobin & hemoglobin	p. 41
Enzymes : mechanism of action	p. 49
Enzymes : kinetics	p. 61
Enzymes : regulation of activities	p. 73
Bioinformatics & computational biology	p. 82
Bioenergetics : the role of ATP	p. 88
Biologic oxidation	p. 94
The respiratory chain & oxidative phosphorylation	p. 100
Carbohydrates of physiologic significance	p. 112
Lipids of physiologic significance	p. 121
Overview of metabolism & the provision of metabolic fuels	p. 132
The citric acid cycle : the catabolism of acetyl-CoA	p. 145
Glycolysis & the oxidation of pyruvate	p. 151
Metabolism of glycogen	p. 159
Gluconeogenesis & the control of blood glucose	p. 167
The pentose phosphate pathway & other pathways of hexose metabolism	p. 177
Oxidation of fatty acids : ketogenesis	p. 187
Biosynthesis of fatty acids & eicosanoids	p. 196
Metabolism of acylglycerols & sphingolipids	p. 209
Lipid transport & storage	p. 217
Cholesterol synthesis, transport, & excretion	p. 230
Biosynthesis of the nutritionally nonessential amino acids	p. 241
Catabolism of proteins & of amino acid nitrogen	p. 246
Catabolism of the carbon skeletons of amino acids	p. 254
Conversion of amino acids to specialized products	p. 270
Porphyrins & bile pigments	p. 279
Nucleotides	p. 294
Metabolism of purine & pyrimidine nucleotides	p. 301
Nucleic acid structure & function	p. 311
DNA organization, replication, & repair	p. 322
RNA synthesis, processing, & modification	p. 348
Protein synthesis & the genetic code	p. 365
Regulation of gene expression	p. 380
Molecular genetics, recombinant DNA, & genomic technology	p. 402
Membranes : structure & function	p. 422
The diversity of the endocrine system	p. 442
Hormone action & signal transduction	p. 464
Nutrition, digestion, & absorption	p. 482
Micronutrients : vitamins & minerals	p. 489
Intracellular traffic & sorting of proteins	p. 506
Glycoproteins	p. 523
The extracellular matrix	p. 545
Muscle & the cytoskeleton	p. 565
Plasma proteins & immunoglobulins	p. 588
Hemostasis & thrombosis	p. 606
Red & white blood cells	p. 617
Metabolism of xenobiotics	p. 633
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