The HDL Handbook

by Komoda

• ISBN13: 9780123821713
• ISBN10: 0123821711
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-08-12
• Publisher: Elsevier Science

Summary

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition researchers and clinicians working with an aging population, corporate researchers, postdocs; medical students and graduate students will find this publication useful, as the scope of coverage includes basic science, genetics, epidemiology, treatment of HDL cholesterol, as well as, potential targets to modify HDL cholesterol. Comprehensive coverage of basic science, genetics, epidemiology and treatmentReputable content on latest advances in HDL cholesterol researchInclusive, worldwide content with country specific informationIn depth discussion of potential targets to modify HDL

Author Biography

Dr. Tsugikazu Komoda is a respected professor at Saitama Medical University in Japan and a celebrated researcher in functional biochemistry, general medical chemistry and biological medical chemistry. Since 1996, Dr. Komoda has held the position of Chief Member of the Editorial Board of the Society of Japanese Electrophoresis. He is a member of the following organizations: The Society of Bone and Mineral Metabolism, The Society of Gastroenterology, The Society of Atherosclerosis and Thrombosis, The Society of Japanese Cancer, The Society of Japanese Otolaryngology, The Society of Japanese Diabetology and Japan Human Proteome Organisation.

Table of Contents

Preface	p. vii
List of Contributors	p. ix
Role of Phospholipid Transfer Protein in HDL Remodeling and Atherosclerosis	p. 1
The Role of Cholesteryl Ester Transfer Protein (CETP) in HDL Metabolism	p. 17
Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology	p. 35
HDL and Reverse Cholesterol Transport: Physiological Modulation	p. 61
Serum Paraoxonase (PON1) and its Interactions with HDL: Relationship between PON1 and Oxidative Stress	p. 77
Paraoxonase-1 and its Interactions with HDL: Molecular Structures of PON1 and HDL	p. 99
Apolipoprotein A-l Mutations	p. 133
The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling	p. 153
HDL Mimetic Peptides: Novel Therapeutic Strategies for the Treatment of Inflammatory Vascular Disease	p. 179
Sterol Efflux by ABCA1 and ABCG1	p. 199
Functional Change in the HDL Particle by Oxidative Modification and its Contribution to Atherogenesis	p. 215
Preßl-HDL, a Native Lipid-poor HDL, and its Potential as a New Marker for HDL Metabolism	p. 243
Determination of Circulating Native and Denaturated HDL Concentrations and its Clinical Implications	p. 261
Index	p. 277
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