Health Risk Assessment

by Wang, Rhoda G. M.; Knaak, James B.; Maibach, Howard I.

• ISBN13: 9780849373572
• ISBN10: 0849373573
• Format: Hardcover
• Copyright: 1993-01-01
• Publisher: CRC Pr I Llc

Summary

Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.

Table of Contents

Physiologically Based Pharmacokinetic Modeling to Predict Tissue Dose and Cholinesterase Inhibition in Workers Exposed to Organophosphorus and Carbamate Pesticides	p. 3
The Application of Pharmacokinetic Models to Predict Target Dose	p. 31
Cytochrome P450-Dependent Metabolism of Drugs and Carcinogens in Skin	p. 47
Percutaneous Absorption	p. 63
In Vitro Skin Metabolism	p. 75
Animal Models for Percutaneous Absorption	p. 89
A Comparative Study of the Kinetics and Bioavailability of Pure and Soil-Absorbed Benzene, Toluene, and m-Xylene after Dermal Exposure	p. 105
Prediction of Human Percutaneous Absorption with Physicochemical Data	p. 117
Dermal Absorption of TCDD: Effect of Age	p. 127
Percutaneous Absorption of Chemicals from Water during Swimming and Bathing	p. 135
Percutaneous Absorption of Contaminants from Soil	p. 145
General Overview on Toxicological Responses and Routes of Chemical Exposure	p. 159
Acute Toxicity Testing by the Dermal Route	p. 167
Subchronic Dermal Exposure Studies with Industrial Chemicals	p. 201
The Dose Response of Percutaneous Absorption	p. 217
Reproductive and Developmental Toxicity Studies by Cutaneous Administration	p. 229
Dermal Carcinogenicity Studies of Petroleum-Derived Materials	p. 263
Comparison of Results from Carcinogenicity Tests of Two Halogenated Compounds by Oral, Dermal, and Inhalation Routes	p. 275
The Objectives and Goals of Dermal Carcinogenicity Testing of Petroleum Liquids	p. 283
Chemical Carcinogenesis in Skin: Causation, Mechanism, and Role of Oncogenes	p. 291
Incorporating Biological Information into the Assessment of Cancer Risk to Humans Under Various Exposure Conditions and Issues Related to High Background Tumor Incidence Rates	p. 309
Phototoxicity of Topical and Systemic Agents	p. 331
Techniques for Assessing the Health Risks of Dermal Contact with Chemicals in the Environment	p. 343
Interspecies Extrapolation of Toxicological Data	p. 387
Human Skin Xenografts to Athymic Rodents as a System to Study Toxins Delivered to or Through the Skin	p. 413
The Isolated Perfused Porcine Skin Flap	p. 439
Perspectives on Assessment of Risk From Dermal Exposure to Polycyclic Aromatic Hydrocarbons	p. 455
The Paradox of Herbicide 2,4-D Epidemiology	p. 471
A Review of Epidemiologic Studies with Regard to Routes of Exposure to Toxicants	p. 491
Index	p. 511
Table of Contents provided by Blackwell. All Rights Reserved.