Hematopathology Pearls

by Zhang, Da

• ISBN13: 9789350259252
• ISBN10: 9350259257
• Edition: 1st
• Format: Paperback
• Copyright: 2012-10-01
• Publisher: Jaypee Brothers Medical Pub

Summary

This review is a step by step guide to hematopathology for students preparing for rotation and examinations. Beginning with an introduction to haematopoiesis and haematology testing, the following chapters examine different types of condition such as red blood cell, platelet and nonneoplastic white blood cell disorders, as well as related diseases including leukaemia, lymphoma and myelodysplastic syndromes. Separate chapters are dedicated to flow cytometry and molecular pathology. Each chapter presents a practical, clinically oriented approach to understanding the basis of the tests, the potential pitfalls (clinical, technical and biological) in their interpretation and resulting prognosis and treatment. Written by US-based Professor D A Zhang, this comprehensive review features more than 325 colour images and illustrations. A Question and Answer section is included to assist students with learning. Key Features Step by step guide to hematopathology for students preparing for rotation and examinations Practical approach through tests, potential pitfalls, interpretation and treatment Detailed discussion on different types of disorders and diseases Includes Question and Answer section More than 325 colour images and illustrations Authored by US specialist, Professor D A Zhang

Author Biography

Da Zhang MD MSc is an Associate Professor of Pathology at the University of Kansas School of Medicine, Kansas City, Kansas, USA. He graduated from Shandong Medical University (currently Shandong University School of Medicine) and received his Master's degree in Immunology and Molecular Biology from the Institute of Virology, Chinese Academy of Preventive Medicine. He was trained as Resident at the Medical University of South Carolina and as a Fellow at Memorial Sloan-Kettering Cancer Center, New York City and was certified in Anatomic Pathology, Clinical Pathology, and Hematology by the American Board of Pathology.

Table of Contents

Hematopoiesis and Hematology Testing	p. 1
Hematopoiesis and Blood Cells	p. 2
Hematology Testing	p. 8
Disorders of Red Blood Cells	p. 13
Anemia	p. 28
Hypochromic, Microcytic Anemia	p. 29
Megaloblastic Anemias	p. 33
Aplastic Anemia and Hypoplastic Anemia	p. 34
Pure Red Blood Cell Aplasia	p. 37
Anemia Related to Hemolysis	p. 38
Anemia Associated with Hemoglobinopathies	p. 43
Other Anemia-related Syndromes	p. 51
Disorders of Platelets and Coagulation Factors	p. 57
Coagulation Factors	p. 58
Coagulation Tests	p. 59
Natural Inhibitors of Coagulation	p. 61
Fibrinolytic System	p. 62
Inherited Coagulation Disorders	p. 63
Acquired Coagulation Disorders	p. 65
Platelets and von Willebrand Factor	p. 68
Hereditary Thrombotic Disorders and Anticoagulant Therapy Monitoring	p. 72
Disorders of Nonneoplastic White Blood Cells	p. 75
Neutrophil Disorders	p. 76
Normal Lymph Node, Thymus and Lymphoid Hyperplasia	p. 91
Normal Lymph Node-Function and Structure	p. 92
Normal Thymus-Function and Structure	p. 93
Predominant Patterns and Etiology of Reactive Lymph Node Hyperplasia	p. 93
Highlighted Topics	p. 95
Spleen	p. 107
Normal Spleen Function and Structure	p. 108
Splenic Lymphomas	p. 109
Myelodysplastic Syndromes	p. 117
Myelodysplastic Syndromes (MDS)	p. 118
Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)	p. 120
Myeloproliferative Neoplasms	p. 124
Acute Myeloid Leukemia	p. 143
WHO Classification and Prognosis	p. 144
AML with Recurrent Genetic Abnormalities	p. 147
AML with Myelodysplasia Related Changes	p. 151
Therapy-related Myeloid Neoplasms (t-AML, t-MDS, t-MDS/MPN)	p. 152
AML Not Otherwise Categorized	p. 153
Acute Leukemias of Ambiguous Lineage	p. 161
Acute Lymphoblastic Leukemia/Lymphoma, Mature T- and B-Cell Leukemias	p. 167
Acute Lymphoblastic Leukemia/Lymphoma (ALL)	p. 168
Mature B-cell Leukemia	p. 175
Mature T-cell Leukemia and Natural Killer Cell-Large Granular Lymphocyte Leukemia (NK-LGLL)	p. 185
Non-Hodgkin Lymphomas, Plasma Cell Neoplasms and Histiocytic/Dendritic Cell Neoplasms	p. 191
Non-Hodgkin Lymphomas	p. 192
Plasma Cell Neoplasms	p. 235
Histocytic and Dendritic Cell Neoplasms	p. 247
Hodgkin Lymphoma	p. 255
Lymphoproliferative Disorders Associated with Immunodeficiency and Post-transplantations	p. 269
Primary Immune Disorders Associated with Lymphoproliferative Disorders	p. 270
Disorders Associated with Acquired Immunodeficiency	p. 271
Post-transplant Lymphoproliferative Disorders	p. 271
Flow Cytometry	p. 275
Principles of Flow Cytometry and its Applications	p. 276
Molecular Pathology	p. 301
Basic Concept and Terminology	p. 302
Methods in Molecular Pathology	p. 311
Genetic Abnormalities and Molecular Basis of Diseases	p. 314
Questions and Answers	p. 321
Appendix	p. 399
Index	p. 407
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