Hematopoietic Growth Factors in Oncology

by Morstyn, George; Foote, Maryann; Lieschke, Graham J.

• ISBN13: 9781588293022
• ISBN10: 1588293025
• Format: Hardcover
• Copyright: 2004-03-01
• Publisher: Humana Pr Inc

Summary

Leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and nonhodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem cell factor and its receptor, C-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology.

Table of Contents

Preface	v
Contributors	ix
Part I. Basic Research
1 Introduction to Hematopoietic Growth Factors: A General Overview	3	(8)
George Morstyn and MaryAnn Foote
2 Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology	11	(34)
Graham J. Lieschke
3 The Jak/Stat Pathway of Cytokine Signaling	45	(20)
Ben A. Croker and Nicos A. Nicola
4 Small-Molecule and Peptide Agonists: A Literature Review	65	(18)
Ellen G. Laber and C. Glenn Begley
Part II. Hematopoietic Growth Factors
5 Granulocyte Colony-Stimulating Factor	83	(14)
Graham Molineux
6 Erythropoietic Factors: Clinical Pharmacology and Pharmacokinetics	97	(28)
Steven Elliott, Anne C. Heatherington, and MaryAnn Foote
7 Thrombopoietin Factors	125	(28)
David J. Kuter
8 Stem Cell Factor and Its Receptor, c-Kit	153	(32)
Keith E. Langley
9 Hematopoietic Growth Factors: Preclinical Studies of Myeloid and Immune Reconstitution	185
Ann M. Farese and Thomas J. MacVittie
Part III. Use of Hematopoietic Growth Factors in Oncology
10 Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors	211	(8)
Richard M. Fox
11 Neutropenia and the Problem of Fever and Infection in Patients With Cancer	219	(16)
David C. Dale
12 Thrombocytopenia and Platelet Transfusions in Patients With Cancer	235	(14)
Lawrence T. Goodnough
13 Hematopoietic Growth Factors in Lung Cancer	249	(26)
Johan F. Vansteenkiste and Christophe A. Dooms
14 Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin's and Non-Hodgkin's Lymphomas	275	(10)
Marcie R. Tomblyn and Jane N. Winter
15 Use of Granulocyte Growth Factors in Breast Cancer	285	(26)
Eric D. Mininberg and Frankie Ann Holmes
16 Role of Cytokines in the Management of Chronic Lymphocytic Leukemia	311	(22)
Carol Ann Long
17 Hematopoietic Growth Factor Therapy for Myelodysplastic Syndromes and Aplastic Anemia	333	(24)
Jason Gotlib and Peter L. Greenberg
18 Use of Hematopoietic Growth Factors in AIDS-Related Malignancies	357	(18)
MaryAnn Foote
Part IV. Safety and Economic Implications
19 The Safety of Hematopoietic Growth Factors	375	(20)
Roy E. Smith and Barbara C. Good
20 Long-Term Safety of Filgrastim in Chronic Neutropenias	395	(14)
Karl Welte
21 Economics of Hematopoietic Growth Factors	409	(38)
Gary H. Lyman and Nicole M. Kuderer
Part V. Future Directions
22 Potential for Hematopoietic Growth Factor Antagonists in Oncology	447	(20)
Hayley S. Ramshaw, Timothy R. Hercus, Ian N. Olver, and Angel F. Lopez
Acronyms and Selected Abbreviations	467	(8)
Index	475