Hematopoietic Stem Cells 2000: Basic and Clinical Sciences : Third International Conference

by Orlic, Donald; Kanz, Lothar; Brumendorf, Tim H.; Sharkis, Saul J.

• ISBN13: 9780801870415
• ISBN10: 0801870410
• Edition: 1st
• Format: Paperback
• Copyright: 2002-03-01
• Publisher: Johns Hopkins Univ Pr

Summary

The genetics of stem cell development and stem cell transplantation are advancingknowledge of these fields at a breathtaking pace. This volume presents the latestdevelopments in the rapidly advancing field of hematopoietic stem cells, includingembryonic stem cells. Internationally known basic and clinical scientists present theirfindings in stem cell biology in vivo and in vitro, including molecular controls,microenvironment, regulators of hematopoiesis, in vivo human stem cell assays, clinicalstudies, and genetics of hematopoietic disorders.

Table of Contents

Preface	ix
Donald Orlic
Tim H. Brummendorf
Saul J. Sharkis
Lothar Kanz
Part I. Stem Cells in Cycle
Limited Telomere Shortening in Hematopoietic Stem Cells after Transplantation	1	(8)
Tim H. Brummendorf
Nathalie Rufer
Gabriela M. Baerlocher
Eddy Roosnek
Peter M. Lansdorp
Ex vivo Expansion and Engraftment Potential of Cord Blood-Derived CD34+ Cells in NOD/SCID MiCc	9	(9)
Willem E. Fibbe
Willy A. Noort
Frank Schipper
Roel Willemze
Quantitative Assessment of the Stem Cell Self-Renewal Capacity	18	(8)
Hiromitsu Nakauchi
Kazuhiro Sudo
Hideo Ema
Part II. Stem Cell Mobilization and Engraftment
Transendothelial Migration of Hematopoietic Progenitor Cells: Role of Chemotactic Factors	26	(10)
Robert Mohle
Frank Bautz
Claudio Denzlinger
Lothar Kanz
Mobilization of Endothelial and Hematopoietic Stem and Progenitor Cells by Adenovector-mediated Elevation of Serum Levels of SDF-1, VEGF, and Angiopoietin-1	36	(12)
M.A.S. Moore
K. Hattori
B. Heissig
J.H. Shieh
S. Dias
R.G. Crystal
S. Rafii
Increase of Circulating SDF-1 after Treatment with Sulfated Glycans: The Role of SDF-1 in Mobilization	48	(6)
Elizabeth A. Sweeney
Thalia Papayannopoulou
Stem Cell Engraftment Strategies	54	(9)
P.J. Quesenberry
F.M. Stewart
P. Becker
Lionel D'Hondt
A. Frimberger
J.F. Lambert
G.A. Colvin
C. Miller
C. Heyes
Merhdad Abedi
M. Dooner
J. Carlson
J. Reilly
C. McAuliffe
K. Stencel
K. Ballen
R. Emmons
P. Doyle
S. Zhong
H. Wang
H. Habibian
Characterization of Human Hematopoietic Cells with Short-Lived in Vivo Re- populating Activity	63	(9)
C. Eaves
H. Glimm
W. Eisterer
J. Audet
V. Maguer-Satta
J. Piret
Divisional History and Pluripotency of Human Hematopoietic Stem Cells	72	(11)
Michael Punzel
Anthony D. Ho
Mechanism of Human Stem Cell Migration and Repopulation of NOD/SCID and B2mnull NOD/SCID Mice: The Role of SDF-1/CXCR4 Interactions	83	(13)
Tsvee Lapidot
Part III. Genetics of Hematopoiesis
Regulation of Hemangioblast Development	96	(13)
Georges Lacaud
Scott Robertson
James Palis
Marion Kennedy
Gordon Keller
Role of the Microenvironment of the Embryonic Aorta-Gonad-Mesonephros Region in Hematopoiesis	109	(8)
Mitsuo Nishikawa
Tomoyuki Tahara
Atsushi Hinohara
Atushi Miyajima
Tatsutoshi Nakahata
Akihiro Shimosaka
Part IV. Cytokine and Chemokine Regulation of Stem Cells
Chemokine Regulation of Hematopoiesis and the Involvement of Pertussis Toxin-Sensitive Gαi Proteins	117	(12)
Hal E. Broxmeyer
Byung S. Youn
Chang Kim
Giao Hangoc
Scott Cooper
Charlie Mantel
Pathways in Cytokine Regulation of Hematopoiesis	129	(2)
James Ihle
Hematopoietic Growth Factor Mimetics	131	(8)
Kenneth Kaushansky
Part V. Biology of Stem Cells
CD34 Expression by Murine Hematopoietic Stem Cells: Developmental Changes and Kinetic Alterations	139	(7)
Makio Ogawa
Fumihito Tajima
Tatsuya Ito
Takashi Sato
Joseph H. Laver
Takao Deguchi
A Model for the Detection of Clonality in Marked Hematopoietic Stem Cells	146	(11)
Manfred Schmidt
Hanno Glimm
Nina Lemke
Arne Muessig
Carsten Speckmann
Sebastian Haas
Philipp Zickler
Gesa Hoffmann
Christof von Kalle
Observations of Residual Differentiation Potential during Lineage Commitment	157	(10)
William B. Slayton
Mariluz P. Mojica
L. Jeanne Pierce
Gerald J. Spangrude
Dendritic Cell Development from Common Myeloid Progenitors	167	(8)
Markus G. Manz
David Traver
Koichi Akashi
Miriam Merad
Toshihiro Miyamoto
Edgar G. Engleman
Irving L. Weissman
The Monoclonal Antibody W7CS Defines a Novel Surface Antigen on Hematopoietic Stem Cells	175	(9)
Christina Giesert
Graca Almeida-Porada
Alexander Scheffold
Lothar Kanz
Esmail D. Zanjani
Hans-Jorg Buhring
In vivo Dynamics of Human Stem Cell Repopulation in NOD/SCID Mice	184	(7)
John E. Dick
Guillermo Guenechea
Olga I. Gan
Craig Dorrell
Phenotype and Function of Hematopoietic Stem Cells	191	(5)
Saul J. Sharkis
Sara Neutzel
Michael I. Collector
Mucin-like Molecules as Modulators of the Survival and Proliferation of Primitive Hematopoietic Cells	196	(12)
Paul J. Simmons
Jean-Pierre Levesque
David N. Haylock
Part VI. Stem Cell Plasticity
Stem Cell Plasticity in Muscle and Bone Marrow	208	(13)
Margaret A. Goodell
Kathyjo Ann Jackson
Susan M. Majka
Tiejuan Mi
Hongyu Wang
Jennifer Pocius
Craig J. Hartley
Mark W. Majesky
Mark L. Entman
Lloyd H. Michael
Karen K. Hirschi
Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice	221	(10)
Donald Orlic
Jan Kajstura
Stefano Chimenti
David M. Bodine
Annarosa Leri
Piero Anversa
Characterization of Multipotent Adult Progenitor Cells, a Subpopulation of Mesenchymal Stem Cells	231	(5)
Morayma Reyes
Catherine M. Verfaillie
Part VII. Gene Transfer
The Impact of ex Vivo Cytokine Stimulation on Engraftment of Primitive He-matopoietic Cells in a Non-Human Primate Model	236	(10)
Cynthia E. Dunbar
Masaaki Takatoku
Robert E. Donohue
Development of a Stable Retrovirus Vector Capable of Long-Term Expression of γ-Globin mRNA in Mouse Erythrocytes	246	(16)
Denise E. Sabatino
Nancy E. Seidel
Amanda P. Cline
Stacie M. Anderson
Patrick G. Gallagher
David M. Bodine
RD114-Pseudotyped Oncoretroviral Vectors: Biological and Physical Properties	262	(16)
Patrick F. Kelly
Jody Carrington
Amit Nathwani
Elio F. Vanin
Part VIII. Malignant Hematopoiesis
Lineage Commitment and Maturation Induction in Normal and Leukemic Preprogenitor Cells	278	(15)
D. Metcalf
Y. Laabi
Telomere Length Dynamics in Normal Individuals and in Patients with Hematopoietic Stem Cell-Associated Disorders	293	(12)
Tim H. Brummendorf
Nathalie Rufer
Tessa L. Holyoake
Jarek Maciejewski
Michael J. Barnett
Connie J. Eaves
Allen C. Eaves
Neal Young
Peter M. Lansdorp
Implications of Mutations in Hematopoietic Growth Factor Receptor Genes in Congenital Cytopenias	305	(23)
Manuela Germeshausen
Matthias Ballmeier
Karl Welte
Non-Myeloablative Hematopoietic Cell Transplantation: Replacing High-Dose Cytotoxic Therapy by the Graft-versus-Tumor Effect	328	(12)
Lyle Feinstein
Brenda Sandmaier
David Maloney
Peter A. McSweeney
Michael Maris
Christopher Flowers
Jerry Radich
Marie-Therese Little
Richard A. Nash
Thomas Chauncey
Ann Woolfrey
George Georges
Hans-Peter Kiem
Jan M. Zaucha
Karl G. Blume
Judith Shizuru
Dietger Niederwieser
Ranier Storb
Immunological Aspects of Haploidentical Stem Cell Transplantation in Children	340	(19)
R. Handgretinger
P. Lang
M. Schumm
M. Pfeiffer
S. Gottschling
B. Demirdelen
P. Bader
S. Kuci
T. Klingebiel
D. Niethammer
Dendritic Cell-Based Vaccines in Patients with Hematological Malignancies	359	(6)
Wolfram Brugger
Anya Schneider
Theodora Schammann
Patricia Dill
Frank Grunebach
Hans-Jorg Buhring
Lothar Kanz
Peter Brossart
Index of contributors	365