Hematopoietic Stem Cells V, Volume 1044

by Kanz, Lothar; Weisel, Katja C.; Orlic, Donald; Fibbe, Willem E.

• ISBN13: 9781573315890
• ISBN10: 1573315893
• Edition: 1st
• Format: Paperback
• Copyright: 2005-06-24
• Publisher: Wiley-Blackwell

Summary

The most recent developments in hematopoietic stem cell research are presented in this volume, along with their clinical implications. The field of hematopoietic stem cell biology is rapidly advancing, and new ideas and concepts supported by fascinating new technologies captivated the interest and excitement of the participants of the meeting.The sharing of new ideas and technologies with other scientists represents an invaluable stimulus, particularly for the young investigators in the field. It is hoped that the spirit of the meeting will be carried forward to the readers of this volume and that its content will stimulate new and fruitful projects in the field of stem cell biology.The major topics covered are genetic and epigenetic regulation of stem cells, stem cell plasticity, stem cell regulation and self-renewal, and embryonic stem cells as well as malignant stem cell biology.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Lothar Kanz is the editor of Hematopoietic Stem Cells V, Volume 1044, published by Wiley. Katja C. Weisel is the editor of Hematopoietic Stem Cells V, Volume 1044, published by Wiley.

Table of Contents

Introduction	ix
Donald Orlic
Katja C. Weisel
Willem E. Fibbe
Lothar Kanz
Part I. Malignant Hematopoiesis
Acute Myeloid Leukemia Stem Cells	1	(5)
John E. Dick
Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold	6	(10)
Hannes Klump
Bernhard Schiedlmeier
Christopher Baum
Developmental Impact of Leukemic Fusion Genes on Stem Cell Fate	16	(8)
Tariq Enver
Shinobu Tsuzuki
John Brown
Dengli Hong
Rajeev Gupta
Tony Ford
Minenori-Ishimae Egucchi
Mariko Egucchi
Mel Greaves
Part II. Early Hematopoiesis
Derivation of the Hematopoietic Stem Cell Compartment from Human Embryonic Stem Cell Lines	24	(5)
Mickie Bhatia
Thrombopoietin Regulates Differentiation of Rhesus Monkey Embryonic Stem Cells to Hematopoietic Cells	29	(12)
Zheng Wang
Julia Skokowa
Andri Pramono
Matthias Ballmaier
Karl Welte
The Vascular Wall as a Source of Stem Cells	41	(10)
Manuela Tavian
Bo Zheng
Estelle Oberlin
Mihaela Crisan
Bin Sun
Johnny Huard
Bruno Peault
Genetic and Functional Characterization of Isolated Stromal Cell Lines from the Aorta-Gonado-Mesonephros Region	51	(9)
Katja C. Weisel
Malcolm A.S. Moore
Part III. Mobilization
Involvement of Proteases in Cytokine-Induced Hematopoietic Stem Cell Mobilization	60	(10)
Gerjo A. Velders
Willem E. Fibbe
Hematopoietic Stem Cell Transplantation across Major Genetic Barriers: Tolerance Induction by Megadose CD34 Cells and Other Veto Cells	70	(14)
Yair Reisner
Hilit Gur
Shlomit Reich-Zeliger
Massimo F. Martelli
Esther Bachar-Lustig
The Role of Sphingosine 1-Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells	84	(6)
Gabriele Seitz
Andreas M. Boehmler
Lothar Kanz
Robert Mohle
Part IV. Gene Expression in Stem Cells
Epigenetic Regulation of Normal and Cancer Stem Cells	90	(4)
Michael F. Clarke
Distinct Gene Expression Pattern of Malignant Hematopoietic Stem and Progenitor Cells in Polycythemia Vera	94	(15)
Ulrich Steidl
Thomas Schroeder
Christian Steidl
Guido Kobbe
Thorsten Graef
Simone Bork
Sabrina Pechtel
Slawomir Kliszewski
Andrea Kuendgen
Ulrich P. Rohr
Roland Fenk
Michael Schroeder
Detlef Haase
Rainer Haas
Ralf Kronenwett
Hox Genes: From Leukemia to Hematopoietic Stem Cell Expansion	109	(8)
Carolina Abramovich
Nicolas Pineault
Hideaki Ohta
R. Keith Humphries
Part V. Plasticity
Engraftment of Bone Marrow-Derived Epithelial Cells	117	(8)
Diane S. Krause
Lineage Promiscuity and Plasticity in Hematopoietic Development.	125	(7)
Koichi Akashi
Stem Cell Biology: A View toward the Future	132	(7)
Ihor R. Lemischka
Part VI. Regulators
Thrombopoietin and the Hematopoietic Stem Cell	139	(3)
Kenneth Kaushansky
Role of GATA-1 in Normal and Neoplastic Hemopoiesis	142	(17)
Anna Rita Migliaccio
Rosa Alba Rana
Alessandro M. Vannucchi
Francesco A. Manzoli
Gene Expression in Stem Cell-Supporting Stromal Cell Lines	159	(9)
Pierre Charbord
Kateri Moore
Effect of Tyrosine Kinase Inhibition Using Imatinib on Normal Lymphohematopoietic Cells	168	(10)
Stefan Balabanov
Silke Appel
Lothar Kanz
Peter Brossart
Tim H. Brummendorf
Part VII. Clonality
Stem Cell Gene Transfer: Insights into Integration and Hematopoiesis from Primate Genetic Marking Studies	178	(5)
Cynthia E. Dunbar
Clonal Multilineage Differentiation of Murine Common Pluripotent Stem Cells Isolated from Skeletal Muscle and Adipose Stromal Cells	183	(18)
Jamie Case
Tamara L. Horvath
Jonathan C. Howell
Mervin C. Yoder
Keith L. March
Edward F. Srour
Tracking Hematopoiesis at the Single Cell Level	201	(9)
Timm Schroeder
Lymphoid Potential of Primitive Bone Marrow Progenitors Evaluated In Vitro	210	(10)
Hongfang Wang
L. Jeanne Pierce
Gerald J. Spangrude
Part VIII. Self-Renewal
Role of Telomerase in Hematopoietic Stem Cells	220	(8)
Peter M. Lansdorp
The Stem Cell Continuum	228	(8)
Peter J. Quesenberry
Gerald A. Colvin
Mehrdad Abedi
Gerri Dooner
Mark Dooner
Jason Aliotta
Patrick Keaney
Luguang Luo
Delia Demers
Abigail Peterson
Bethany Foster
Deborah Greer
Human Adaptive Immune System Rag2 γc Mice	236	(9)
Laurie Chicha
Roxane Tussiwand
Elisabetta Traggiai
Luca Mazzucchelli
Lucio Bronz
Jean-Claude Piffaretti
Antonio Lanzavecchia
Markus G. Manz
Index of Contributors	245