Hematopoietic Stem Cells VI, Volume 1106

by Kanz, Lothar; Weisel, Katja C.; Dick, John; Fibbe, Willem E.

• ISBN13: 9781573316767
• ISBN10: 1573316768
• Edition: 1st
• Format: Paperback
• Copyright: 2007-07-23
• Publisher: Wiley-Blackwell

Summary

Stem cell research holds great promise for therapeutic applications. This rapidly advancing field is the focus of the biennial international symposium and workshop whose proceedings are contained within this volume.The major topics covered are stem cell function, including self-renewal, survival, migration, and regulation; the stem cell niche; stem cell fate as lineage commitment takes place; malignant hematopoiesis; hematopoiesis regulators; and embryonic stem cells and plasticity.As with previous volumes in this unique series of proceedings, it is hoped that further cooperation and collaborative projects will be generated by disseminating these presentations widely.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Lothar Kanz is the editor of Hematopoietic Stem Cells VI, Volume 1106, published by Wiley. Katja C. Weisel is the editor of Hematopoietic Stem Cells VI, Volume 1106, published by Wiley.

Table of Contents

Introduction	p. xi
Stem Cell Function
AMD3100 and CD26 Modulate Mobilization, Engraftment, and Survival of Hematopoietic Stem and Progenitor Cells Mediated by the SDF-1/CXCL12-CXCR4 Axis	p. 1
The Stem Cell Continuum: Cell Cycle, Injury, and Phenotype Lability	p. 20
Inference, Validation, and Dynamic Modeling of Transcription Networks in Multipotent Hematopoietic Cells	p. 30
Stem Cell Niche
Maintenance of Quiescent Hematopoietic Stem Cells in the Osteoblastic Niche	p. 41
Cytokine Signaling, Lipid Raft Clustering, and HSC Hibernation	p. 54
Dormant and Self-Renewing Hematopoietic Stem Cells and Their Niches	p. 64
Stem Cell Fate
Cartography of Hematopoietic Stem Cell Commitment Dependent upon a Reporter for Transcription Factor Activation	p. 76
Gradients of Antigen Expression and Developmental Potential in Hematopoiesis	p. 82
Biological and Molecular Evidence for Existence of Lymphoid-Primed Multipotent Progenitors	p. 89
Malignant Hematopoiesis
Insertional Mutagenesis by Replication-Deficient Retroviral Vectors Encoding the Large T Oncogene	p. 95
NUP98 Dysregulation in Myeloid Leukemogenesis	p. 114
Regulators
LEF-1 Is a Decisive Transcription Factor in Neutrophil Granulopoiesis	p. 143
Role of Thrombopoietin in Mast Cell Differentiation	p. 152
Thrombopoietic Cells and the Bone Marrow Vascular Niche	p. 175
Differential Effects of G Protein-Coupled Receptors on Hematopoietic Progenitor Cell Growth Depend on their Signaling Capacities	p. 180
Effect of FLT3 Inhibition on Normal Hematopoietic Progenitor Cells	p. 190
Embryonic Stem Cells and Plasticity
The Cdx-Hox Pathway in Hematopoietic Stem Cell Formation from Embryonic Stem Cells	p. 197
Differentiation Potential of Histocompatible Parthenogenetic Embryonic Stem Cells	p. 209
Hematopoiesis from Human Embryonic Stem Cells	p. 219
Emergence of Human Angiohematopoietic Cells in Normal Development and from Cultured Embryonic Stem Cells	p. 223
Stem Cell Exhaustion
Epigenetic Control of Hematopoietic Stem Cell Aging: The Case of Ezh2	p. 233
Telomere Length in Human Natural Killer Cell Subsets	p. 240
Mesenchymal Stem Cells and Transplantation
Flt3 in Regulation of Type I Interferon-Producing Cell and Dendritic Cell Development	p. 253
Novel Markers for the Prospective Isolation of Human MSC	p. 262
Modulation of Immune Responses by Mesenchymal Stem Cells	p. 272
Feasibility and Outcome of Reduced-Intensity Conditioning in Haploidentical Transplantation	p. 279
Index of Contributors	p. 291
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