Hemophilia

by Forbes, C. D.; Aledort, L. M.; Madhok, R.

• ISBN13: 9780412638206
• ISBN10: 0412638207
• Format: Hardcover
• Copyright: 1997-03-20
• Publisher: Hodder Education Publishers

Summary

This book provides comprehensive information on the current status of the clinical and laboratory aspects of hemophilia. as relevant to the practising physician and those involved in providing care for hemophiliacs. The international authorship gives the text world-wide relevance withcontributors selected because of established pre-eminence in their specialist fields. The book is divided into four sections: the basic science chapters provide an update account of the molecular basis of coagulation relevant to the subject and extend to cover in detail the molecular pathology ofthe hemophilias. Clinical practice outlines the diagnosis of hemophilia and the clinical approach to hemophiliac bleeding according to system, specific sections are then dedicated to treatment and the complications of treatment, and the psycho-social aspects of hemophilia.

Table of Contents

Color plates appear between pages 116 and 117
List of contributors	vii	(4)
Preface	xi
Part One: Understanding Hemophilia	3	(50)
1 The early history of hemophilia	3	(4)
C. D. Forbes
2 Hemostatic mechanisms: why hemophiliacs bleed	7	(14)
O. D. Ratnoff
3 The molecular defect in hemophilia A	21	(14)
G. Kemball-Cook
E. G. D. Tuddenham
4 The molecular biology of hemophilia B	35	(18)
H. R. Roberts
D. K. Liles
Part Two: Clinical Features	53	(106)
5 The diagnosis of hemophilia A and B and von Willebrand's disease	53	(10)
K. A. Rickard
6 Diagnosis of hemophilia A and B carriers and prenatal diagnosis	63	(12)
A. C. Goodeve
I. R. Peake
7 Genetic counseling in hemophilia	75	(12)
D. E. Wilcox
J. M. Connor
8 Central and peripheral nervous system bleeding	87	(16)
J. P. Hanley
C. A. Ludlam
9 Oral bleeding	103	(12)
S. Sindet-Pedersen
10 Musculoskeletal bleeding in hemophilia	115	(8)
R. Madhok
11 Pseudotumors (hemophilic blood cysts)	123	(10)
M. S. Gilbert
12 Hemophilia and sport	133	(10)
P. M. Jones
B. M. Buzzard
13 Visceral bleeding	143	(16)
M. J. Inwood
Part Three: Treatment and Complications	159	(176)
14 The treatment of hemophilia: comprehensive hemophilia care	159	(6)
L. M. Aledort
15 Principles of management of hemophiliac bleeding	165	(6)
S. V. Seremetis
16 Home therapy	171	(10)
M. W. Hilgartner
D. Cardi
I. Goldberg
17 Factor VIII concentrates	181	(12)
E. Berntorp
18 Desmopressin (DDAVP)	193	(10)
S. Lethagen
19 Factor IX concentrates	203	(10)
J. M. Lusher
20 Inhibitors in hemophilia	213	(16)
L. W. Hoyer
21 Bleeding in the hemophilia carrier	229	(8)
I. A. Greer
I. D. Walker
22 Management of hemophilia during surgery	237	(12)
N. L. Kobrinsky
D. A. Stegman
23 Infectious complications of blood products	249	(10)
B. L. Evatt
W. C. Hooper
24 Liver disease in hemophilia	259	(16)
M. E. Eyster
25 HIV-1 infection in hemophilia	275	(20)
J. J. Goedert
B. L. Kroner
26 Non-infectious complications of hemophilia	295	(12)
C. R. M. Hay
P. H. B. Bolton-Maggs
27 Safer clotting factor concentrates	307	(28)
P. R. Foster
B. Cuthbertson
R. V. McIntosh
A. J. MacLeod
Part Four: Psychosocial Aspects	335	(36)
28 The family and hemophilia	335	(12)
I. Markova
29 The cost of hemophilia care	347	(8)
R. A. Lipton
30 Psychosocial services in hemophilia	355	(12)
L. J. Haas
J. R. Schultz
M. A. Rigdon
31 Life assurance in hemophilia	367	(4)
P. Wilkie
Index	371