Hepatitis Delta Virus

by Handa, Hiroshi; Yamaguchi, Yuki, Ph.D.

• ISBN13: 9780387322308
• ISBN10: 0387322302
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-04-25
• Publisher: Landes Bioscience

Summary

Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this book describes one of the broad aspects of HDV from virology to molecular biology, and from diagnosis to therapy.

Table of Contents

Preface	vii
1. Genotype of Hepatitis Delta Virus	1	(9)
Nobuyuki Enomoto, Hideki Watanabe, Kazuyoshi Nagayama, Tsuyoshi Yamashiro and Mamoru Watanabe
Classification of HDV Genotype	1	(1)
Geographical Distribution of HDV Genotype	1	(1)
Clinical Significance of HDV Genotype	1	(3)
Virological Significance of HDV Genotype	4	(6)
2. Hepatitis Delta Virus: HDV-HBV Interactions	10	(10)
Camille Sureau
The Structure of the HDV Particle	11	(1)
Are HBV Helper Functions Limited to Supplying Envelope Proteins to HDV?	12	(1)
Why Is HBV Best Suited for Assisting HDV?	12	(3)
How Do S-HBsAg and the RNP Interact with Each Other for HDV Assembly?	15	(3)
The Infectivity of the HDV Virions	18	(1)
What Are the Effects of HDV Infection on the HBV Life Cycle?	18	(2)
3. Structure and Replication of Hepatitis Delta Virus RNA	20	(18)
John M. Taylor
The RNAs	20	(2)
RNA Structure	22	(1)
Experimental Systems for the Initiation of HDV Replication	23	(1)
RNA-Directed Transcription	24	(2)
Template-Switching and Recombination	26	(1)
Post-Transcriptional Processing	27	(4)
RNA Assembly	31	(1)
Models of Genome Replication	31	(7)
4. Hepatitis Delta Antigen: Biochemical Properties and Functional Roles in HDV Replication	38	(14)
Michael M.C. Lai
Structural and Functional Domains of HDAg	38	(1)
RNA-Binding Domains	38	(1)
Nuclear Localization Signal (NLS)	39	(1)
Coiled-Coil Sequence	40	(1)
The C-Terminal 19-Amino Acid Extension of L-HDAg	40	(1)
Phosphorylation	40	(2)
Subcellular Localization of HDAg	42	(1)
Functions of HDAg in HDV Replication	42	(3)
RNA Chaperone and Enhancement of Ribozyme Activity	45	(1)
Other Activities	45	(1)
Regulation of the Synthesis of S- and L-HDAg	45	(1)
The Roles of HDAg in HDV RNA Synthesis	46	(1)
The Cytotoxic Effects of HDAg	47	(1)
Perspectives	47	(5)
5. Hepatitis Delta Virus RNA Editing	52	(14)
John L. Casey
What Is RNA Editing?	52	(1)
Mechanism of HDV RNA Editing	53	(3)
Regulation of HDV RNA Editing	56	(6)
Assays for Editing	62	(1)
Future Directions	63	(3)
6. Hepatitis Delta Antigen and RNA Polymerase II	66	(10)
Yuki Yamaguchi and Hiroshi Handa
Variation on a Theme: Initiation, Elongation, and Termination of HDV RNA Transcription	67	(3)
HDAg as a Viral Transcription Elongation Factor	70	(3)
Molecular Analysis of Elongation Control by HDAg	73	(1)
Targeting Transcription Elongation: A General Strategy for Viruses?	73	(3)
7. Clinical Features of Hepatitis Delta Virus	76	(5)
Dimitrios Vassilopoulos and Stephanos Hadziyannis
Acute Hepatitis Delta	77	(4)
8. Diagnosis of Hepatitis D Virus Infection	81	(12)
Jaw-Ching Wu
Serological Diagnosis Based on Antibodies to HDAg (Anti-HDV)	82	(2)
Molecular Diagnosis Based on HDAg and HDV RNA	84	(3)
Immuno-Pathologic Diagnosis Based on Hepatic HDAg	87	(2)
Genotypic Diagnosis	89	(1)
Replication Markers of HBV	89	(4)
Index	93