The Hereditary Basis of Allergic Diseases

by Holgate, Stephen T.; Holloway, John W.

• ISBN13: 9783764364021
• ISBN10: 3764364025
• Format: Hardcover
• Copyright: 2002-09-01
• Publisher: Birkhauser

Summary

Allergic diseases are complex and involve a range of environmentalfactors interacting with a susceptible genotype. The familial clusteringof diseases, such as asthma and hay fever, has been recognised for overtwo centuries, but identification of the genetic basis to this had toawait the molecular biological revolution. Estimates of the contributionthat genetic factors make to asthma susceptibility range from 35% to70%. For the majority of allergic diseases, segregation analysis has notidentified a consistent Mendelian pattern of inheritance, which, whencombined with multiple phenotypes and environmental interactions, hasmade identifying candidate genes especially difficult and, at times,controversial. Part of the difficulty has been lack of agreement overphenotype definitions, reduced power of studies to predict linkage andassociation, and, importantly, lack of true heterogeneity betweenpopulations.Despite these difficulties, the last decade has witnessed enormousprogress in this field. Th

Table of Contents

List of contributors	p. vii
Preface	p. xi
Heredity of allergy and asthma	p. 1
Genome scans for asthma	p. 17
The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites	p. 29
Genetic regulation of specific IgE responsiveness	p. 37
Genetic variation at the HLA and TCR loci and the development of allergy and asthma	p. 55
Chromosome 11q13, Fc[varepsilon]RI[beta] and atopic asthma	p. 85
Genetic regulation of interleukin-13 production	p. 95
The role of interleukin-9 and the interleukin-9 receptor gene candidates in asthma	p. 113
Genetics of the nitric oxide synthetic pathway in asthma	p. 125
Genetic regulation of leukotriene production and activity	p. 137
Genetics of asthma severity	p. 167
Index	p. 177
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