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9781588297310

High Content Screening

by ; ;
  • ISBN13:

    9781588297310

  • ISBN10:

    1588297314

  • Edition: CD
  • Format: Hardcover
  • Copyright: 2006-10-31
  • Publisher: Humana Pr Inc

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Summary

High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell. High Content Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery discusses its use as a high throughput platform to understand the functions of genes, RNA, proteins, and other cellular constituents at the level of the living cell. High Content Screening is assembled to assist both existing users of HCS, as well as investigators considering the addition of a discovery-driven platform to their research and development activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents, and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters. Written by a team of world leaders in the field, High Content Screening is essential reading for senior scientists, advanced lab technicians, as well as students/post-docs who wish to apply HCS in their research and development programs.

Table of Contents

Preface v
Contributors xi
Guide to the Companion CD xiii
Part I. Introduction to High Content Screening
Past, Present, and Future of High Content Screening and the Field of Cellomics
3(16)
D. Lansing Taylor
A Pharmaceutical Company User's Perspective on the Potential of High Content Screening in Drug Discovery
19(14)
Ann F. Hoffman
Ralph J. Garippa
Linking Microscopy and High Content Screening in Large-Scale Biomedical Research
33(8)
James G. Evans
Paul Matsudaira
Part II. Instrumentation, Biological Application Software, and Sample Preparation
Requirements, Features, and Performance of High Content Screening Platforms
41(22)
Albert H. Gough
Paul A. Johnston
Characteristics and Value of Directed Algorithms in High Content Screening
63(20)
Richik N. Ghosh
Oleg Lapets
Jeffrey R. Haskins
Characteristics and Value of Machine Learning for Imaging in High Content Screening
83(12)
Juergen A. Klenk
Tools for Quantitative and Validated Measurements of Cells
95(14)
Anne L. Plant
John T. Elliott
Alessandro Tona
Dennis McDaniel
Kurt J. Langenbach
Automated Cell Plating and Sample Treatments for Fixed Cells in High Content Assays
109(12)
Gillian R. Richards
Julie E. Kerby
Grace K. Y. Chan
Peter B. Simpson
Differentiating Primary Human Cells in Rapid-Throughput Discovery Applications
121(8)
Daniel R. Marshak
Dale E. Greenwalt
Use of the CellCard™ System for Analyzing Multiple Cell Types in Parallel
129(12)
Oren Beske
Daniel Bassoni
Simon Goldbard
Part III. Reagents
Reagents to Measure and Manipulate Cell Functions
141(24)
Kenneth A. Giuliano
D. Lansing Taylor
Alan S. Waggoner
Fluorescent Proteins and Engineered Cell Lines
165(24)
Nick Thomas
Optimizing the Integration of Immunoreagents and Fluorescent Probes for Multiplexed High Content Screening Assays
189(6)
Kenneth A. Giuliano
The HaloTag™: A Novel Technology for Cell Imaging and Protein Analysis
195(14)
Georgyi V. Los
Keith Wood
Protein Labeling With FlAsH and ReAsH
209(12)
Thomas Machleidt
Matt Robers
George T. Hanson
Exploiting Network Biology to Improve Drug Discovery
221(12)
Marnie L. MacDonald
John K. Westwick
Physiocological Indicators of Cell Function
233(12)
Michael J. Ignatius
Jeffrey T. Hung
The Use of siRNA to Validate Immunofluorescence Studies
245(8)
K. Gregory Moore
Wayne Speckmann
Ronald P. Herzig
Caged Substrates Applied to High Content Screening: An Introduction With an Eye to the Future
253(16)
Peter G. Conrad, II
Rajesh V. Chavli
Richard S. Givens
Part IV. Informatics and Bioinformatics
Overview of Informatics for High Content Screening
269(12)
R. Terry Dunlay
Wallace J. Czekalski
Mark A. Collins
Large-Scale Data Management for High Content Screening
281(12)
Leon S. Garfinkel
An Integrated Biomedical Knowledge Extraction and Analysis Platform: Using Federated Search and Document Clustering Technology
293(8)
Donald P. Taylor
Visualization of High Content Screening Data
301(18)
Matthew J. Anstett
Pathway Mapping Tools for Analysis of High Content Data Sean
319(34)
Ekins
Yuri Nikolsky
Andrej Bugrim
Eugene Kirillov
Tatiana Nikolskaya
Part V. Assays and Applications of High Content Screening
Systems Biology in Cancer Research: Genomics to Cellomics
353(14)
Jackie L. Stilwell
Yinghui Guan
Richard M. Neve
Joe W. Gray
Target Validation in Drug Discovery
367(12)
Robert A. Blake
High Content Screening as a Screening Tool in Drug Discovery
379(10)
Anthony Nichols
Discovery of Protein Kinase Phosphatase Inhibitors
389(12)
Andreas Vogt
John S. Lazo
High Content Translocation Assays for Pathway Profiling
401(14)
Frosty Loechel
Sara Bjorn
Viggo Linde
Morten Praestegaard
Len Pagliaro
In Vitro Cytotoxicity Assessment
415(12)
Peter O'Brien
Jeffrey Haskins
Neurite Outgrowth in Retinal Ganglion Cell Culture
427(8)
John B. Kerrison
Donald J. Zack
Index 435

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The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

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