High-Throughput Analysis in the Pharmaceutical Industry

by Wang; Perry G.

• ISBN13: 9781420059533
• ISBN10: 142005953X
• Format: Hardcover
• Copyright: 2008-08-20
• Publisher: CRC Press

Summary

High throughput analysis plays a critical role in the pharmaceutical industry. The ever-shortening timelines and high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the industry. Written and edited by well-known contributors who remain active in this line of research, this book systematically describes high throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation. The text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods, with an emphasis on the later stage of drug development, including pharmacokinetics.

Table of Contents

High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries	p. 1
Online Sample Extraction Coupled with Multiplexing Strategy to Improve Throughput	p. 73
Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis	p. 93
Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems	p. 119
High-Throughput Strategies for Metabolite Identification in Drug Discovery	p. 141
Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry	p. 155
Strategies and Techniques for Higher Throughput ADME/PK Assays	p. 205
High-Throughput Analysis in Drug Metabolism during Early Drug Discovery	p. 233
High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry	p. 247
Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis	p. 279
Applications of High-Throughput Analysis in Therapeutic Drug Monitoring	p. 299
High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography-Mass Spectrometry	p. 319
Designing High-Throughput HPLC Assays for Small and Biological Molecules	p. 339
Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development	p. 355
High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry	p. 377
Index	p. 393
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