The Hippocampus Book

by Andersen, Per; Morris, Richard; Amaral, David; Bliss, Tim; O'Keefe, John

• ISBN13: 9780195100273
• ISBN10: 0195100271
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-11-02
• Publisher: Oxford University Press

Summary

The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

Table of Contents

The Hippocampal Function

Historical Perspective: Proposed Functions, Biological Characteristics, and Neurobiological Models of the Hippocampus

Hippocampal Neuroanatomy

Morphological Development of the Hippocampus

Structure and Functional Properties of Hippocampal Neurons

Synaptic Function

Molecular Mechanisms of Synaptic Function in the Hippocampus: Neurotransmitter Exocytosis, Glutamatergic, GABAergic and Cholinergic Transmission

Local Circuits

Structural Plasticity

Synaptic Plasticity in the Hippocampus

Hippocampal Neurophysiology in the Behaving Animal

Functional Roll of the Human Hippocampus

Theories of Hippocampal Function

Computational Models of the Spatial and Mnemonic Functions of the Hippocampus

Stress and the Hippocampus

The Hippocampus and Human Disease

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