Histiocytic Disorders of Children and Adults: Basic Science, Clinical Features and Therapy

by Edited by Sheila Weitzman , R. Maarten Egeler

• ISBN13: 9780511113949
• ISBN10: 0511113943
• eBook ISBN(s): 9780511113949
• Additional ISBN(s): 9780521184168, 9780521839297
• Format: Nonspecific Binding
• Copyright: 2005-09-01
• Publisher: Cambridge University Press

Summary

As a comprehensive reference on all aspects of the histiocytic disorders, Histiocytic Disorders of Children and Adults stands out a seminal text on the genetics, pathophysiology and clinical management of this wide range of diseases. The chapters, written by acknowledged experts in the field, cover all aspects of hystiocytic disorders, from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are discussed in detail. Originally published in 2005, this book will be a valuable resource to clinicians and researchers who wish to learn more about histiocytic disorders.

Table of Contents

Langerhans Cell Histiocytosis

Introduction to the problem: overview, history, epidemiology and classification

The histopathology of Langerhans Cell Histiocytosis

Histiocyte function and the normal immune system

The immunologic basis of Langerhans Cell Histiocytosis

The genetics of Langerhans Cell Histiocytosis

Clinical aspects of Langerhans Cell Histiocytosis

Dermatologic aspects of the Histiocytic disorders

Langerhans Cell Histiocytosis of bone

Special aspects of Langerhans Cell Histiocytosis in the adult

Adult lung Histiocytosis

Central nervous system involvement in Langerhans Cell Histiocytosis

The treatment of Langerhans Cell

Novel and salvage therapies in Langerhans Cell Histiocytosis

Late effects of Langerhans Cell Histiocytosis and malignancy and LCH

Uncommon Histiocytic disorders

Histiocytic Disorders Involving the Monocyte/Macrophage Pathway

The histopathology of haemophagocytic lymphohistiocytosis

Genetics and pathogenesis of hemophagocytic lymphohistiocytosis

Clinical aspects and therapy of hemophagocytic lymphohistiocytosis

Macrophage activation syndrome

Malignant diseases of the mononuclear phagocytic system

Psychosocial aspects of the Histiocytic disorders

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