Histiocytic Disorders of Children and Adults: Basic Science, Clinical Features and Therapy

by Edited by Sheila Weitzman , R. Maarten Egeler

• ISBN13: 9780521184168
• ISBN10: 0521184169
• eBook ISBN(s): 9780511113949
• Edition: 1st
• Format: Paperback
• Copyright: 2011-02-17
• Publisher: Cambridge University Press
• More Book Details

Summary

This comprehensive reference on histiocytic disorders considers the genetics, pathophysiology, and clinical management of this wide range of diseases. It covers all aspects of hystiocytic disorders--from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Current views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are also presented.

Table of Contents

Langerhans Cell Histiocytosis:

Introduction to the problem: overview, history, epidemiology and classification

The histopathology of Langerhans Cell Histiocytosis

Histiocyte function and the normal immune system

The immunologic basis of Langerhans Cell Histiocytosis

The genetics of Langerhans Cell Histiocytosis

Clinical aspects of Langerhans Cell Histiocytosis

Dermatologic aspects of the Histiocytic disorders

Langerhans Cell Histiocytosis of bone

Special aspects of Langerhans Cell Histiocytosis in the adult

Adult lung Histiocytosis

Central nervous system involvement in Langerhans Cell Histiocytosis

The treatment of Langerhans Cell Histiocytosis

Novel and salvage therapies in Langerhans Cell Histiocytosis

Late effects of Langerhans Cell Histiocytosis and malignancy and LCH

Uncommon Histiocytic disorders

Histiocytic Disorders Involving the Monocyte/Macrophage Pathway:

The histopathology of haemophagocytic lymphohistiocytosis

Genetics and pathogenesis of hemophagocytic lymphohistiocytosis

Clinical aspects and therapy of hemophagocytic lymphohistiocytosis

Macrophage activation syndrome

Malignant diseases of the mononuclear phagocytic system

Psychosocial aspects of the Histiocytic disorders

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