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9780521184168

Histiocytic Disorders of Children and Adults: Basic Science, Clinical Features and Therapy

by
  • ISBN13:

    9780521184168

  • ISBN10:

    0521184169

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2011-02-17
  • Publisher: Cambridge University Press

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Summary

This comprehensive reference on histiocytic disorders considers the genetics, pathophysiology, and clinical management of this wide range of diseases. It covers all aspects of hystiocytic disorders--from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Current views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are also presented.

Table of Contents

Langerhans Cell Histiocytosis:
Introduction to the problem: overview, history, epidemiology and classification
The histopathology of Langerhans Cell Histiocytosis
Histiocyte function and the normal immune system
The immunologic basis of Langerhans Cell Histiocytosis
The genetics of Langerhans Cell Histiocytosis
Clinical aspects of Langerhans Cell Histiocytosis
Dermatologic aspects of the Histiocytic disorders
Langerhans Cell Histiocytosis of bone
Special aspects of Langerhans Cell Histiocytosis in the adult
Adult lung Histiocytosis
Central nervous system involvement in Langerhans Cell Histiocytosis
The treatment of Langerhans Cell Histiocytosis
Novel and salvage therapies in Langerhans Cell Histiocytosis
Late effects of Langerhans Cell Histiocytosis and malignancy and LCH
Uncommon Histiocytic disorders
Histiocytic Disorders Involving the Monocyte/Macrophage Pathway:
The histopathology of haemophagocytic lymphohistiocytosis
Genetics and pathogenesis of hemophagocytic lymphohistiocytosis
Clinical aspects and therapy of hemophagocytic lymphohistiocytosis
Macrophage activation syndrome
Malignant diseases of the mononuclear phagocytic system
Psychosocial aspects of the Histiocytic disorders
Table of Contents provided by Publisher. All Rights Reserved.

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