Histopathology

by Damjanov, Ivan; McCue, Peter A.; Chansky, Matthew

• ISBN13: 9780683023343
• ISBN10: 0683023349
• Format: Paperback
• Copyright: 1996-02-01
• Publisher: Williams & Wilkins

Table of Contents

CHAPTER 1 CELL PATHOLOGY	1	(25)
Diagram	1
1.1 Response of the cell to physiologic and pathologic stimuli	1	(2)
1.2 Reaction of the cell to injury	3	(3)
1.3 Cell swelling, vacuolization, and cytoplasmic storage	6	(6)
1.4 Adaptive changes induced by cell injury	12	(4)
1.5 Metaplasia	16	(2)
1.6 Cell death	18
Plate	6
1.1 Vacuolar change	6
1.2 Genetic storage diseases	8
1.3 Cytoplasmic storage	10
1.4 Cellular adaptations	12
1.5 Cellular adaptations in the breast	14
1.6 Metaplasia	16
1.7 Cell death	18
1.8 Necrosis	20
CHAPTER 2 INFLAMMATION AND REPAIR	26	(13)
Diagram	26
2.1 Inflammatory cells	26	(2)
2.2 Schematic presentation of acute inflammation	28	(4)
2.3 Granuloma	32	(4)
2.4 Granulation tissue	36
Plate	26
2.1 Inflammatory cells--electron microscopy	26
2.2 Acute inflammation	28
2.3 Chronic inflammation	30
2.4 Chronic inflammation	32
2.5 Histologic features of various macroscopically distinct forms of inflammation	34
2.6 Repair and healing	36
CHAPTER 3 CIRCULATORY DISTURBANCES	39	(25)
Diagram	39
3.1 Circulatory disturbances	39	(3)
3.2 Clinically important forms of edema	42	(2)
3.3 Major clinically important forms of hemorrhage	44	(4)
3.4 Thrombosis	48	(6)
3.5 Pathogenesis of shock	54
Plate	42
3.1 Edema	42
3.2 Hemorrhage	44
3.3 Hyperemia and congestion	46
3.4 Thrombosis	48
3.5 Embolism	50
3.6 Infarct	52
3.7 Shock	54
CHAPTER 4 NEOPLASIA	64	(28)
Diagram	64
4.1 Cytological differences between normal and neoplastic cells	64	(4)
4.2 Grading of adenocarcinomas	68	(2)
4.3 Epithelial tumors of epidermis and mucosal surfaces	70	(4)
4.4 Adenocarcinoma	74	(8)
4.5 Histogenesis of teratomas	82	(4)
4.6 Principles of immunohistochemistry	86
Plate	64
4.1 Morphology of tumor cells	64
4.2 Cytology of neoplasia	66
4.3 Grading of tumors	68
4.4 Benign epithelial tumors	70
4.5 Malignant epithelial tumors	72
4.6 Malignant epithelial tumors	74
4.7 Benign mesenchymal tumors	76
4.8 Malignant mesenchymal tumors	78
4.9 Mixed tumors	80
4.10 Embryonal tumors	82
4.11 Other tumors	84
4.12 Special techniques--immunohistochemistry	86
4.13 Electron microscopy	88
CHAPTER 5 CARDIOVASCULAR SYSTEM	92	(32)
Diagram	92
5.1 Normal cardiovascular system	92	(6)
5.2 Pathogenesis of atherosclerosis	98	(2)
5.3 Myocardial infarct	100	(1)
5.4 Temporal sequence in the appearance of cells infiltrating a myocardial infarct	100	(2)
5.5 Rheumatic fever	102	(2)
5.6 Various forms of endocarditis	104	(4)
5.7 Cardiomyopathy	108	(6)
5.8 Diseases involving the aorta	114
Plate	98
5.1 Atherosclerosis	98
5.2 Coronary atherosclerosis and myocardial infarcts	100
5.3 Rheumatic carditis	102
5.4 Endocarditis	104
5.5 Myocarditis	106
5.6 Cardiomyopathy	108
5.7 Pericarditis	110
5.8 Neoplasms of the cardiovascular system	112
5.9 Diseases of the aorta and its major branches	114
5.10 Vascular changes caused by hypertension	116
5.11 Vasculitis	118
5.12 Vasculitis	120
CHAPTER 6 RESPIRATORY SYSTEM	124	(28)
Diagram	124
6.1 Normal respiratory system	124	(6)
6.2 Respiratory distress syndrome	130	(2)
6.3 Bacterial pneumonia	132	(2)
6.4 Viral pneumonia	134	(2)
6.5 Pulmonary tuberculosis	136	(2)
6.6 Chronic pneumonia	138	(2)
6.7 Immunological lung injury	140	(2)
6.8 Pneumoconioses	142	(2)
6.9 Chronic bronchitis	144	(2)
6.10 Emphysema	146	(2)
6.11 Lung cancer	148
Plate	130
6.1 Alveolar damage and atelectasis	130
6.2 Bacterial pneumonia	132
6.3 Viral and parasitic pneumonia	134
6.4 Tuberculosis and fungal pneumonia	136
6.5 Chronic pneumonia	138
6.6 Immune-mediated lung disease	140
6.7 Chronic interstitial pneumonia	142
6.8 Chronic obstructive pulmonary disease	144
6.9 Neoplasms of the lung	146
6.10 Neoplasms of the lung and pleura	148
CHAPTER 7 HEMATOPOIETIC SYSTEM	152	(28)
Diagram	152
7.1 Normal blood cells in circulation	152	(1)
7.2 Hematopoietic and lymphoid organs--thymus, lymph node, spleen, bone marrow	152	(6)
7.3 Morphology of RBCs in various forms of anemia	158	(2)
7.4 Morphology of RBCs in various forms of anemia	160	(2)
7.5 Bone marrow in anemia	162	(4)
7.6 FAB classification of acute leukemias	166	(6)
7.7 Cells of malignant lymphomas	172	(2)
7.8 Histopathology of Hodgkin disease	174
Plate	158
7.1 Anemia	158
7.2 Anemia	160
7.3 Bone marrow changes in anemia	162
7.4 Consequences and complications of anemia	164
7.5 Acute leukemias	166
7.6 Chronic leukemias	166
7.7 Tissue infiltrates in leukemia	170
7.8 Malignant lymphoma	172
7.9 Hodkin disease (HD)	174
7.10 Plasma cell neoplasia	176
CHAPTER 8 DIGESTIVE SYSTEM	180	(32)
Diagram	180
8.1 Normal digestive system	180	(6)
8.2 Most common infections of the upper digestive tract	186	(4)
8.3 Gastritis and peptic ulcer	190	(2)
8.4 Peptic ulcer	192	(2)
8.5 Gastric neoplasms	194	(2)
8.6 Small intenstinal lesions associated with malabsorption	196	(4)
8.7 Circulatory disturbances of the intestine	200	(2)
8.8 Appendicitis	202	(2)
8.9 Non-neoplastic intestinal polyps	204	(2)
8.10 Neoplastic polyps	206
Plate	186
8.1 Inflammation of the upper digestive system	186
8.2 Neoplasms of the upper digestive system	188
8.3 Gastritis	190
8.4 Peptic ulcer	192
8.5 Tumors of the stomach	194
8.6 Small intestinal lesions associated with malabsorption	196
8.7 Inflammatory bowel disease	198
8.8 Circulatory disorders and diverticulosis	200
8.9 Intestinal infections	202
8.10 Non-neoplastic polyps	204
8.11 Neoplastic polyps	206
8.12 Malignant neoplasms	208
CHAPTER 9 HEPATOBILIARY SYSTEM	212	(31)
Diagram	212
9.1 Normal hepatobiliary system	212	(8)
9.2 Biliary obstruction	220	(6)
9.3 Viral hepatitis	226
Plate	220
9.1 Obstructive jaundice	220
9.2 Metabolic disorders	222
9.3 Alcohol-induced liver changes	224
9.4 Acute viral hepatitis	226
9.5 Massive hepatic necrosis	228
9.6 Chronic hepatitis	230
9.7 Bacterial and parasitic hepatitis	232
9.8 Immunologic liver diseases	234
9.9 Cirrhosis	236
9.10 Liver tumors	238
9.11 Gallbladder diseases	240
CHAPTER 10 PANCREAS	243	(15)
Diagram	243
10.1 Normal pancreas	243	(5)
10.2 Acute pancreatic necrosis	248	(1)
Plate	248
10.1 Acute pancreatitis	248
10.2 Cystic fibrosis and meconium peritonitis	250
10.3 Pancreatic neoplasms	252
10.4 Diabetes mellitus	254
CHAPTER 11 URINARY SYSTEM	258	(40)
Diagram	258
11.1 Normal urinary tract	258	(1)
11.2 Normal glomerulus	259	(9)
11.3 Glomerular changes in nephrotic syndrome	268	(4)
11.4 Glomerular changes in nephritic syndrome	272	(6)
11.5 Crescentic glomerulonephritis	278	(6)
11.6 Developmental kidney diseases	284	(10)
11.7 Urinary bladder cancer	294
Plate	268
11.1 Lipoid nephrosis and focal segmental sclerosis	268
11.2 Membranous nephropathy	270
11.3 Poststreptococcal glomerulonephritis	272
11.4 Lupus nephritis	274
11.5 Membranoproliferative glomerulonephritis	276
11.6 Crescentic glomerulonephritis	278
11.7 IgA nephropathy, chronic glomerulonephritis	280
11.8 Vascular diseases	282
11.9 Developmental kidney diseases	284
11.10 Tubulointerstitial nephritis and tubular necrosis	286
11.11 Pyelonephritis	288
11.12 Renal tumors	290
11.13 Cystitis	292
11.14 Urinary bladder tumors	294
CHAPTER 12 MALE REPRODUCTIVE SYSTEM	298	(21)
Diagram	298
12.1 Normal male reproductive system	298	(8)
12.2 Epididymo-orchitis	306	(2)
12.3 Histogenesis of testicular germ cell tumors	308	(6)
12.4 Prostate	314
Plate	304
12.1 Developmental and genetic disorders	304
12.2 Infections	306
12.3 Carcinoma in situ and seminoma	308
12.4 Nonseminomatous germ cell tumors	310
12.5 Sex cord tumors and metastases	312
12.6 Prostatic diseases	314
12.7 Diseases of penis	316
CHAPTER 13 FEMALE GENITAL SYSTEM	319	(32)
Diagram	319
13.1 Normal female reproductive system	319	(7)
13.2 Infectious lesions of the female reproductive system	326	(6)
13.3 Carcinoma of the cervix	332	(6)
13.4 Ovarian neoplasms	338	(2)
13.5 Ovarian tumors of surface ("germinal") epithelium	340	(1)
13.6 Serous tumor	340	(4)
13.7 Germ cell tumors	344	(2)
13.8 Sex cord cell tumors	346
Plate	326
13.1 Vulvovaginitis	326
13.2 Inflammation of uterus and fallopian tubes	328
13.3 Vulvar dystrophy and carcinoma	330
13.4 Cervical neoplasia	332
13.5 Endometrial hormonal changes	334
13.6 Neoplasms of the uterus	336
13.7 Ovarian cysts	338
13.8 Ovarian neoplasms of surface epithelium	340
13.9 Ovarian neoplasms of surface epithelium	342
13.10 Germ cell tumors	344
13.11 Sex cord cell tumors, stromal cells and metastases	346
13.12 Pathology of pregnancy	348
CHAPTER 14 BREAST	351	(19)
Diagram	351
14.1 Normal breast	351	(7)
14.2 Fibrocystic change	358	(4)
14.3 Carcinoma of breast	362
Plate	356
14.1 Non-neoplastic lesions	356
14.2 Fibrocystic change	358
14.3 Gynecomastia and benign tumors	360
14.4 Intraductal carcinomas	362
14.5 Infiltrating duct carcinoma	364
14.6 Variants of breast carcinoma	366
CHAPTER 15 ENDOCRINE GLANDS	370	(27)
Diagram	370
15.1 Normal endocrine glands	370	(12)
15.2 Thyroiditis	382	(2)
15.3 Thyroid tumors	384	(2)
15.4 Parathyroid diseases	386	(2)
15.5 Adrenal cortical diseases	388	(4)
15.6 Embryogenesis and tumors of adrenal medulla	392
Plate	376
15.1 Pituitary adenoma	376
15.2 Diseases causing hypopituitarism	378
15.3 Non-neoplastic thyroid diseases	380
15.4 Thyroiditis	382
15.5 Thyroid tumors	384
15.6 Parathyroid lesions	386
15.7 Adrenal lesions	388
15.8 Adrenal cortical hyperfunction	390
15.9 Adrenal medulla	392
CHAPTER 16 SKIN	397	(25)
Diagram	397
16.1 Normal skin	397	(7)
16.2 Principal skin lesions	404	(4)
16.3 Infectious diseases (viral)	408	(2)
16.4 Infectious diseases (bacterial and fungal)	410	(2)
16.5 Immune diseases	412	(2)
16.6 Tumors of epithelial cells	414	(2)
16.7 Pigmented lesions	416
Plate	404
16.1 Idiopathic skin diseases	404
16.2 Lesions caused by exogenous physical injury	406
16.3 Infectious diseases (viral)	408
16.4 Infectious diseases (bacterial and fungal)	410
16.5 Immunological diseases	412
16.6 Neoplasms (epithelial)	414
16.7 Pigmented lesions	416
16.8 Dermal tumors	418
CHAPTER 17 BONES AND JOINTS	422	(26)
Diagram	422
17.1 Anatomy and histology of a typical long bone	422	(6)
17.2 Developmental disorders of the bone	428	(2)
17.3 Metabolic bone diseases	430	(1)
17.4 Rickets	430	(2)
17.5 Osteitis fibrosa caused by hyperparathyroidism	432	(2)
17.6 Healing of fracture	434	(4)
17.7 Bone tumors	438	(2)
17.8 Osteoarthritis	440	(2)
17.9 Rheumatoid arthritis	442
Plate	428
17.1 Developmental disorders	428
17.2 Metabolic disorders	430
17.3 Metabolic disorders	432
17.4 Osteomyelitis and fractures	434
17.5 Benign bone tumors	436
17.6 Malignant bone tumors	438
17.7 Osteoarthritis	440
17.8 Rheumatoid arthritis	442
17.9 Other joint diseases	444
CHAPTER 18 SKELETAL MUSCLES	448	(12)
Diagram	448
18.1 Normal skeletal muscle	448	(2)
18.2 Denervation of muscle due to nerve injury with subsequent reinnervation	450	(2)
18.3 Myopathic pattern of muscle injury	452
Plate	450
18.1 Neurogenic atrophy of the muscles	450
18.2 Muscular dystrophy	452
18.3 Myopathy	454
18.4 Myositis	456
CHAPTER 19 NERVOUS SYSTEM	460	(31)
Diagram	460
19.1 Components of the nervous system	460	(10)
19.2 Important infections of the CNS	470	(6)
19.3 Multiple sclerosis	476	(4)
19.4 Alzheimer disease	480	(2)
19.5 Neurodegenerative, nutritional, and toxic disorders	482	(2)
19.6 Most common histological features of intracranial tumors	484
Plate	466
19.1 Reaction of neurons	466
19.2 Reaction of glia cells to injury	468
19.3 Infectious diseases--meningitis	470
19.4 Infectious diseases--encephalitis	472
19.5 Infectious diseases--AIDS	474
19.6 Demyelinating diseases	476
19.7 Cerebrovascular diseases	478
19.8 Alzheimer disease	480
19.9 Nutritional deficiencies and toxic diseases	482
19.10 Neoplasms--astrocytic tumors	484
19.11 Neoplasms--astrocytic tumors	486
19.12 Meningiomas, nerve sheath tumors, and mesenchymal tumors	488
Index	491