HIV/AIDS and the Nervous System

by Portegies; Berger

• ISBN13: 9780444520104
• ISBN10: 0444520104
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-08-17
• Publisher: Elsevier Science

Summary

This volume in the Handbook of Clinical Neurology (Series Editors: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) covers the neurological aspects of HIV/AIDS. The complications of AIDS described include opportunistic infections, central nervous system tumours, spinal cord disorders, peripheral neuropathies and progressive encephalopathy. The advances in molecular biology and the advent of other investigative techniques are described that have transformed the understanding of the basic mechanisms of the disease and the development of therapeutic strategies. Despite the much improved prognosis provided by antiretroviral therapy, the situation is different in the developing world and a chapter highlights the neurological aspects of HIV/AIDS as found there. This volume gives a comprehensive account invaluable both to the clinical neurologist and neuroscience researcher. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Table of Contents

Foreword	p. vii
List of contributors	p. ix
Introduction to HIV infection and neuro-AIDS	p. 1
Neuroepidemiology of HIV/AIDS	p. 3
HIV neurology in the developing world	p. 33
The neuropathogenesis of HIV-1 infection	p. 45
Neurological sequelae of primary HIV infection	p. 69
AIDS dementia complex	p. 79
Neurocognitive assessment of persons with HIV disease	p. 93
HIV myelopathy	p. 123
Peripheral neuropathy in HIV infection	p. 129
Myopathy in HIV infection	p. 139
Cerebral toxoplasmosis in AIDS	p. 147
Cryptococcal infection	p. 159
Progressive multifocal leukoencephalopathy	p. 169
Other opportunistic infections of the central nervous system in AIDS	p. 185
Primary central nervous system lymphoma	p. 221
Neuroimaging of the HIV/AIDS patient	p. 229
Cerebrospinal fluid markers in central nervous system HIV infection and AIDS dementia complex	p. 261
The neuropathology of HIV	p. 301
Neuropharmacology of HIV/AIDS	p. 319
Subject index	p. 369
Color plate section	p. 373
Table of Contents provided by Ingram. All Rights Reserved.