Hormonal Carcinogenesis III: Proceedings of the Third International Symposium

by Li, Jonathan J.

• ISBN13: 9780387951270
• ISBN10: 038795127X
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-12-01
• Publisher: SPRINGER

Summary

This volume contains the proceedings of the Third International Symposium on Hormonal Carcinogenesis held September 6-12, 1998, in Seattle, Washington. It is clear that breast and prostate cancers are by far the most common cancers in developed countries and have similar incidences worldwide. Endometrial and ovarian cancers also occur at relatively high frequencies in women. Sex hormones have emerged as major culprits in the development of these neoplasms. This Symposium brings together basic scientists, epidemiologists, and clinicians from a wide range of disciplines to present the latest research developments aimed to elucidate the involvement of hormones in the etiology, promotion, and progression in neoplastic transformation of target tissues as well as their prevention. Therapeutic indices related to these hormonally-related cancers is also presented, including benefits and risks.

Table of Contents

Dedication	v
Acknowledgments	vi
Preface	ix
Participants	xxi
Contributors	xxix
Symposium Address
Hormonal Carcinogenesis: Perceptions, Challenges, and Anticipations	1	(22)
Gerald C. Mueller
STATE OF THE ART LECTURES	23	(36)
The Numbers Game with Estrogen Receptors and Growth Regulation	25	(12)
Jack Gorski
Tae-Yon Chun
Douglas Wendell
Expression Genetics of Hormone Dependent Human Tumors	37	(7)
Arthur B. Pardee
Heide L. Ford
Debajit K. Biswas
Katherine J. Martin
Ruth Sager
New Directions in Epidemiologic Studies of Hormonally-related Cancers	44	(15)
Janet R. Daling
Kathleen E. Malone
Elaine A. Ostrander
Peggy L. Porter
PART 1. EPIDEMIOLOGY: BREAST AND PROSTATE CANCER	59	(38)
Estrogen Causes Breast Cancer: Increasing Duration of Use of Postmenopausal Hormones Increases the Risk of Breast Cancer	61	(9)
Graham A. Colditz
Frequency of BRCA2 Mutations in Women with Early Onset Breast Cancer Drawn from a Population-Based Study	70	(17)
Kathleen E. Malone
Janet R. Daling
Nicola M. Suter
Kara Cushing
Thora Jonnasdottir
Elaine A. Ostrander
Prostate Cancer, Androgens, and Estrogens	87	(10)
Janet L. Stanford
PART 2. MOLECULAR GENETICS OF HORMONAL CANCERS	97	(40)
Introduction
Breast Cancer Molecular Cytogenetics	99	(4)
Frederic M. Waldman
Genome Scanning and Tissue Microarrays for the Analysis of Molecular Mechanisms Underlying Hormone Therapy Failure in Prostate Cancer	103	(10)
Lukas Bubendorf
Olli-P Kallioniemi
Serial Analysis of Gene Expression in Breast Cancer Cells	113	(11)
C. Marcelo Aldaz
Andrzej Bednarek
April Charpentier
Michael MacLeod
Kathleen Hawkins
Kendra Laflin
The Effects of Triphenylethylene Antiestrogens on Parameter of Multistage Hepatocarcinogenesis in the Rat	124	(13)
Yvonne P. Dragan
Emile Nuwaysir
Linda Sargent
Dong-hui Li
V. Craig Jordan
Henry C. Pitot
PART 3. ESTROGEN RECEPTOR INTERACTIONS	137	(22)
Introduction
The Curious Pharmacology of the Antiestrogens	139	(5)
Elwood V. Jensen
Estrogen Receptor β: An Important Player in Estrogen Action	144	(5)
Jan-Ake Gustafsson
Estrogen Receptor Mediated Genomic Instability in the Syrian Hamster Kidney: A Critical Event in Hormonal Oncogenesis	149	(10)
Jonathan J. Li
S. John Weroha
Marilyn Cansler
Sara Antonia Li
PART 4. ESTROGEN/PROGESTERONE-BREAST CANCER	159	(40)
Introduction
Breast Cancer Prevention with Estrogen and Progesterone: Mimicking the Protective Effect of Pregnancy	161	(5)
Satyabrata Nandi
Raphael C. Guzman
Jason Yang
Lakshmanaswamy Rajkumar
Gudmundur Thordarson
The Dual Role of Estrogens and Cathepsin D in Invasion and Metastasis	166	(12)
Henri Rochefort
Estrogen-induced Breast Cancer in Female ACI Rats	178	(11)
Sara Antonia Li
Joshua DeZhong Liao
Jonathan J. Li
A Transgenic Mouse Model for Mammary Carcinogenesis	189	(10)
Kristen L. Murphey
Jeffrey M. Rosen
PART 5. CELL CYCLE, CELL PROLIFERATION	199	(30)
Introduction
Receptor Tyrosine Kinases and the Effects of Ovarian Steroids on Cell Proliferation	201	(5)
Richard P. DiAugustine
Diane M. Klotz
R. Gregg Richards
Transcriptional Control of Cell Cycle Progression by Estrogenic Hormones: Regulation of Human Cyclin D1 Gene Promoter Activity by ER-α	206	(14)
Valeria Belsito Petrizzi
Luigi Cicatiello
Lucia Altucci
Raffaele Addeo
Raphaelle Borgo
Massimo Cancemi
Massimo Ancora
Juan Leyva
Francesco Bresciani
Alessandro Weisz
Estrogen Regulation of Cell Cycle Progression	220	(9)
Owen W.J. Prall
Eileen M. Rogan
Elizabeth A. Musgrove
Colin K.W. Watts
Robert L. Sutherland
PART 6. ONCOGENES/TUMOR SUPPRESSOR GENES	229	(32)
Estrogen and c-myc Protooncogene Actions in Human Breast Cancer	231	(7)
Robert P.C. Shiu
D. Dubik
M. Venditti
J. Sparling
B. Iwasiow
Peter H. Watson
Steroid Hormone Regulation of Vascular Endothelial Growth Factor (VEGF) Production: A Potential Step in Hormonal Carcinogenesis	238	(12)
Salman M. Hyder
Holly L. Boettger-Tong
Sari Makela
George M. Stancel
TGF-β/Estrogen-inducible Early Gene (TIEG): A Candidate Tumor Suppressor or Cell Cycle Regulator?	250	(11)
Thomas C. Spelsberg
Malayannan Subramaniam
Katrina M. Waters
Theresa E. Hefferan
David J. Rickard
Gregory G. Reinholz
PART 7. AROMATASE: IMPLICATIONS FOR BREAST CANCER	261	(38)
Introduction
Aromatase: Implications for Breast Cancer	263	(4)
Gregory A. Reed
Control of Estrogen Biosynthesis in Breast Cancer	267	(10)
Shiuan Chen
Dujin Zhou
Yeh-Chih Kao
Chun Yang
Baiba Grube
Regulation of Aromatase in Normal and Malignant Breast Tissues: The Role of the Immune System	277	(8)
A. Singh
A. Purohit
M.W. Ghilchik
M.J. Reed
Regulation of Aromatase in Breast Cancer and Correlation of Aromatase and Cyclooxygenase Gene Expression	285	(14)
Robert W. Brueggemeier
Anne L. Quinn
Yasuro Sugimoto
Young C. Lin
Michelle L. Parrett
Farahnaz S. Joarder
Randell E. Harris
Fredika M. Robertson
PART 8. ORGAN SITE: PROSTATE/OVARY	299	(44)
Introduction
Androgen Receptor and its Role in the Development and Control of Androgen-independent Prostate Cancer	301	(6)
Shutsung Liao
John M. Kokontis
Richard A. Hiipakka
Etiologic Mechanisms in Epithelial Ovarian Cancer	307	(13)
Harvey A. Risch
Stromal Influences in Prostatic Carcinogenesis	320	(13)
Gerald R. Cunha
Simon W. Hayward
Thea Tlsty
Gary D. Grossfeld
Androgen Receptor Structure and Function in Prostate Cancer	333	(10)
Grant Buchanan
Wayne D. Tilley
PART 9. OSTEOPOROSIS AND ESTROGENS	343	(20)
Introduction
Hormone Replacement Therapy: A Clinical Overview	345	(3)
James H. Pickar
Role of Estrogen and Bone Morphogentic Protein Signaling in Osteoblast Differentiation	348	(9)
Stephen E. Harris
Estrogens and the Skeleton	357	(6)
Michael Kleerekoper
PART 10. CARDIOVASCULAR DISEASE AND ESTROGENS/PROGESTINS	363	(20)
Mechanisms of Estrogen Action on the Cardiovascular System	365	(7)
John C. Stevenson
Atherosclerosis and Hormone Replacement Therapy: The Role of Estrogen in Secondary Prevention of Cardiovascular Events	372	(11)
Jay M. Sullivan
VIEWPOINT	383	(18)
Long-term Hormone Replacement Therapy: A Contrary Point of View	385	(16)
Jacques E. Rossouw
EPILOGUE	401	(132)
A Unified General Mechanism for Hormonal Carcinogenesis Begins to Emerge	403	(130)
Jonathan J. Li
Sara Antonia Li
COMMUNICATIONS
Epidemiology/Human Studies	407	(28)
The Risk of Postmenopausal Breast Cancer After Estrogen and Estrogen-Progestin Replacement	409	(4)
C. Magnusson
Ingemar R. Persson
E. Weiderpass
N. Correia
No Significant Difference in Age at Menarche, Menstrual Cycle Length, Age at First Full Term Pregnancy, and Nulliparity among BRCA1 Mutation Carriers Compared with Their Unaffected Relatives	413	(5)
Helena Jernstrom
O. Johannsson
Ake Borg
H. Olsson
Cell Proliferation and Apoptosis in the Normal Breast Epithelium of Pre, Peri, and Postmenopausal Women	418	(6)
Seema A. Khan
Scott Stickles
Expression and Estrogen Inducible Promoter Activity of Human Estrogen-responsive Finger Protein Gene in Breast and Ovarian Cancer Cells	424	(5)
Kazuhiro Ikeda
Satoshi Inoue
Akira Orimo
Hiroi Fujiko Tsuchiya
Itsuo Gorai
Yasuhiro Higashi
Masami Muramatsu
Novel Small Molecule IL-6 Inhibitors as Anti-Cancer Drugs	429	(6)
Bernd Stein
May Sutherland
Stephanie Lipps
Joseph Lewcock
Helen Brady
Lynn Ransone
Metabolism Studies/Cellular & Molecular Biology	435	(98)
Cellular Transforming Activity and Genotoxic Effects of 17β-Estradiol and Its Eight Metabolites in Syrian Hamster Embryo Cells	437	(7)
Takeki Tsutsui
Yukiko Tamura
J. Carl Barrett
Evidence for an Initiation Mechanism of 17β Estradiol Carcinogenesis	444	(7)
Fu-Li Yu
Mian-Ying Wang
Wanda Bender
Estradiol Metabolism by Rat Liver Microsomes from Strains Differing in Susceptibility to Mammary Carcinogenesis	451	(5)
Gregory A. Reed
Angela M. Wilson
Janete K. Padgitt
Induction of Breast Cancer in Noble Rats with a Combination of Estrogen and Testosterone	456	(8)
Y.C. Wong
B. Xie
S.W. Tsao
Isolation and Purification of Breast Carcinoma Cell Lines from a Noble Rat	464	(7)
B. Xie
S.W. Tsao
Y.C. Wong
The ACI Rat as a Genetically Defined Animal Model for the Study of Estrogen Induced Mammary Cancers	471	(6)
Martin Tochacek
Eric A. Vander Woude
Thomas J. Spady
Djuana M.E. Harvell
Mary C. Synder
Karen L. Pennington
Tanya M. Reindl
James D. Shull
Characteristics of Dehydroepiandrosterone-induced Hepatocarcinogenesis in the Rat	477	(7)
Doris Mayer
Christel Metzger
Dirk Nehrbass
Peter Bannasch
Hepatic Toxicity of Estrogen in Armenian and Chinese Hamsters	484	(5)
John E. Coe
Kamal G. Ishak
M.J. Ross
Suppression of Liver Tumor Formation by the Liver Microenvironment of Female, but Not Male, Syngeneic Hosts	489	(7)
Gary J. Smith
Sharon C. Presnell
William B. Coleman
Joe W. Grisham
Dietary Energy Restriction Inhibits Estrogen Induced Pituitary Tumorigenesis in a Rat Strain Specific Manner	496	(6)
Djuana M.E. Harvell
Thomas J. Spady
Tracy E. Strecker
Athena M. Lemus-Wilson
Karen L. Pennington
Fangchen Shen
Diane F. Birt
Rodney D. McComb
James D. Shull
Estrogen-induced Prolactinoma Development: A Role for Cell-Cell Communication	502	(7)
Shane T. Hentges
Dipak K. Sarkar
Combined Administration of Transplacental Ethylnitrosourea and Postnatal Diethylstilbestrol Induce Neural Differentiation in Interstitial Cells of the Golden Hamster Kidney	509	(5)
Amando Peydro-Olaya
Carmen Carda
Antonio Llombart-Bosch
Aromatase Overexpression: Is Aromatase an Oncogene?	514	(7)
Rajeshwar Rao Tekmal
Kiran Gill
Nameer Kirma
Genetic Toxicity In Vitro of Bisphenol A-Diglycidylether (BADGE) and its Hydrolysis Products	521	(6)
Erika Pfeiffer
Manfred Metzler
Lack of Genotoxicity of Major Mammalian and Plant Lignans at Various Endpoints In Vitro	527	(6)
Sabine E. Kulling
Eric Jacobs
Manfred Metzler
Index	533