Hormone Replacement Therapy and Cancer: The Current Status of Research and Practice

by Genazzani; Andrea R.

• ISBN13: 9781842140796
• ISBN10: 1842140795
• Format: Hardcover
• Copyright: 2002-02-11
• Publisher: CRC Press

Summary

The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area.Many of the world's leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of specific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.

Table of Contents

List of principal contributors	ix
Section I: Carcinogenesis
Oncogenes and tumor suppressor genes	1	(9)
S. Giordano
S. Corso
P. Conrotto
Telomerase and cancer	10	(7)
S. S. R. Banik
C. M. Counter
Matrix metalloproteinases	17	(8)
S. McDonnell
A. O'Connor
D. Murray
C. C. Lynch
Biological basis of angiogenesis and role of vascular endothelial growth factor-D	25	(6)
S. Oliviero
Section II: HRT and breast cancer
Breast cancer: epidemiology, pathology and natural history	31	(7)
R. K. Ross
Genes and heredity in breast cancer	38	(6)
G. Bevilacqua
Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant breast epithelium	44	(10)
J. R. Pasqualini
G. S. Chetrite
Chemoprevention of breast cancer with tamoxifen: recent experience and future perspectives	54	(7)
B. Bonanni
A. Guerrieri-Gonzaga
N. Rotmensz
A. Decensi
Hormonal therapy of breast cancer	61	(11)
A. Hamilton
Hormone replacement therapy and mammographic breast density	72	(6)
B. von Schoultz
E. Lundstrom
Hormone replacement therapy, insulin-like growth factor I and breast cancer	78	(8)
P. Sismondi
N. Biglia
R. Ponzone
S. Ambroggio
Postmenopausal hormone use and breast cancer risk: reassessment of the evidence	86	(9)
P. Kenemans
G.A. van Unnik
The use of hormonal therapy for management of severe postmenopausal symptoms following breast cancer	95	(10)
B. G. Wren
Section III: HRT and endometrial cancer
Endometrial cancer: epidemiology, pathology and natural history	105	(10)
J. Prat
Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant endometrial epithelium	115	(10)
E.-M. Rutanen
Chemoprevention and endocrine therapy of endometrial carcinoma	125	(10)
A. R. Genazzani
A. Gadducci
Hormone replacement therapy and endometrial cancer	135	(13)
C. W. Burger
G. A. van Unnik
P. Kenemans
Endometrial stromal tumors - are they hormonally sensitive?	148	(7)
P. E. Schwartz
M. C. Chu
W. Zheng
G. Mor
Section IV: HRT and colon cancer
Epidemiology of colorectal cancer	155	(6)
M. E. Leon
P. Boyle
Colon cancer: Pathology and natural history	161	(11)
F. Tonelli
Estrogen receptors, estrogens and colon cancer	172	(6)
F. Al-Azzawi
Cyclo-oxygenase-2: an endogenous tumor promoter and target for the chemoprevention of colorectal cancer and other neoplastic diseases	178	(13)
F. Marks
G. Furstenberger
K. Muller-Decker
Hormone replacement therapy and colon cancer	191	(7)
A. H. Wu
Section V: HRT and melanoma
Cutaneous malignant melanoma: epidemiology, endocrine features and hormone replacement therapy	198	(9)
A. Gadducci
A. R. Genazzani
Section VI: HRT and epithelial ovarian cancer
BRCA1-BRCA2 and ovarian cancer	207	(11)
S. Greggi
Estrogen replacement therapy use and risk of ovarian cancer: results from two Italian studies and review of the literature	218	(4)
F. Parazzini
G. Polverino
S. Cipriani
E. Ricci
F. Chiaffarino
C. La Vecchia
Section VII: Selective aspects of specific therapies
Understanding HRT risks and benefits and the new science of HRT	222	(13)
J. V. Fiorica
Pulsed estrogen therapy may lead to lower breast stimulation than with daily continuous estrogen exposure	235	(6)
N. Mabon
C. Varin
Y. Tsouderos
Transdermal estrogen therapy and the risk of breast cancer: a clinical appraisal	241	(8)
M. Notelovitz
The effects of selective estrogen receptor modulators on the endometrium	249	(3)
S. R. Goldstein
Safety and tolerability profile of Livial	252	(5)
F. A. Helmond
H. J. Kloosterboer
Preclinical and clinical development of new progesterone receptor antagonists with high receptor specificity for breast cancer treatment	257	(8)
J. Hoffmann
H. Hess-Stumpp
R. B. Lichtner
U. Fuhrmann
G. Siemeister
M. R. Schneider
More than bones: hormone replacement therapy for mind and body	265	(8)
J. M. Alt
Index	273