Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry

by Edited by Mary F. Morrison

• ISBN13: 9780521653046
• ISBN10: 0521653045
• Format: Hardcover
• Copyright: 2000-06-12
• Publisher: Cambridge University Press

Summary

The significance of hormone action in psychiatry has been long studied, now including the psychiatric effects of hormones on the aging process. This clinical reference addresses the hormonal basis of mental disorders in older people. Hormones influence a wide range of states and conditions, from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: · An overview of the basic science of neurosteroids · Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity · Psychoneuroimmunology in relation to age · Sex differences and hormones in psychotropic drug metabolism in the elderly

Table of Contents

List of contributors	ix
Preface	xiii
Acknowledgments	xvii
Part I Overview
Summary chapter. The endocrine basis of geriatric psychiatry: an integrative approach	3	(12)
John E. Morley
Overview of steroids in the aging brain	15	(22)
Loretta M. Flanagan-Cato
Part II Hormones and mental health in the elderly
The hypothalamic--pituitary--adrenal axis in aging: preclinical and clinical studies	37	(16)
John W. Kasckow
Thomas D. Geracioti Jr
Marta Pisarska
Ajit Regmi
Dewleen G. Baker
James J. Mulchahey
The hypothalamic--pituitary--thyroid axis	53	(31)
Gabriel K. Tsuboyama
Estrogen and depression in aging women	84	(30)
Mary F. Morrison
Kathryn Tweedy
The role of testosterone in male depression	114	(30)
Stuart N. Seidman
Steven P. Roose
Dehydroepiandrosterone in aging and mental health	144	(24)
Owen M. Wolkowitz
Patricia D. Kroboth
Victor I. Reus
Tanya J. Fabian
Sex hormones, cognition, and dementia in the elderly	168	(15)
Kristine Yaffe
Effects of estrogen on basal forebrain cholinergic neurons and cognition: implications for brain aging and dementia in women	183	(40)
Robert B. Gibbs
Gender and schizophrenia	223	(18)
Laurie A. Lindamer
M. Jackuelyn Harris
Julie Akiko Gladsjo
Robert Heaton
Jane S. Paulsen
Shelley C. Heaton
Dilip V. Jeste
Sex steroids and anxiety disorders	241	(26)
Teresa A. Pigott
Gender and hormonal factors in pain and pain inhibition	267	(22)
Wendy F. Sternberg
Part III Effects of hormones and behavior on immune function
Estrogens, stress, and psychoneuroimmunology in women over the lifespan	289	(13)
Mary H. Burleson
Susan Robinson-Whelen
Ronald Glaser
Janice K. Kiecolt-Glaser
Gender differences in immune function at the cellular level	302	(19)
Eva Redei
Suresh G. Shelat
Part IV Hormones and gender differences in psychotropic drug metabolism
Gender differences in psychotropic drug metabolism	321	(13)
Bruce G. Pollock
The influence of progesterone on the pharmacokinetics and pharmacodynamics of gamma-aminobutyric acid-active drugs	334	(17)
Patricia D. Kroboth
James W. McAuley
Index	351