Hormones, Genes, and Cancer

by Henderson, Brian E.; Ponder, Bruce; Ross, Ronald K.

• ISBN13: 9780195135763
• ISBN10: 0195135768
• Format: Hardcover
• Copyright: 2003-03-13
• Publisher: Oxford University Press

Summary

Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.

Table of Contents

Contributors	xi
Introduction and Background	1	(11)
Brian E. Henderson
Roberta McKean-Cowdin
Biosynthesis, Transport, and Metabolism of Steroid Hormones	12	(26)
Frank Z. Stanczyk
Philip Bretsky
The Nuclear Receptor Superfamily	38	(61)
John M. Rosenfeld
Hung-ying Kao
Ronald M. Evans
Genomic Approaches to the Genetics of Hormone-Responsive Cancer	99	(21)
Joel N. Hirschhorn
Celeste Leigh Pearce
David Altshuler
Breast Cancer: Epidemiology and Molecular Endocrinology	120	(19)
Heather Spencer Feigelson
The Impact of Exogenous Hormone Use on Breast Cancer Risk	139	(18)
Gillian K. Reeves
Emily Banks
Timothy J.A. Key
An Overview of Genetic Predisposition and the Search for Predisposing Genes for Breast Cancer	157	(12)
Bruce Ponder
Estrogen Biosynthesis Genes: P-450 Aromatase	169	(12)
Colin D. Clyne
Evan R. Simpson
Estrogen Metabolism Genes: HSD17B1 and HSD17B2	181	(18)
Hellevi Peltoketo
Veli Isomaa
Debashis Ghosh
Pirkko Vihko
Breast Cancer: Intervention in BRCA1 and BRCA2 Families	199	(11)
Frances V. Elmslie
Rosalind A. Eeles
Implications of Hormones and Hormonal Risk Factors on Screening Strategies	210	(8)
Giske Ursin
Hormonal Chemoprevention with Tamoxifen and Selective Estrogen Receptor Modulators	218	(30)
David J. Bentrem
V. Craig Jordan
Other Hormonal Prevention Strategies	248	(7)
Darcy V. Spicer
Malcolm C. Pike
Progression from Hormone-Dependent to Hormone-Independent Breast Cancer	255	(18)
Isabell A. Schmitt
Milana Dolezal
Michael F. Press
Prostate Cancer: Epidemiology and Molecular Endocrinology	273	(15)
Ronald K. Ross
Nick M. Makridakis
Juergen K. V. Reichardt
Androgen Receptor Signaling in Prostate Cancer	288	(28)
Wayne D. Tilley
Grant Buchanan
Gerhard A. Coetzee
Hereditary Prostate Cancer: The Search for Major Genes and the Role of Genes Involved in Androgen Action	316	(15)
Bao-Li Chang
Aubrey R. Turner
William B. Isaacs
Jianfeng Xu
Androgen-Independent Prostate Cancer Progression: Mechanistic Insights	331	(12)
George V. Thomas
Charles L. Sawyers
Hormonal Therapies for Prostate Cancer	343	(28)
David I. Quinn
Derek Raghavan
Endometrial Cancer: Epidemiology and Molecular Endocrinology	371	(27)
Linda S. Cook
Jennifer A. Doherty
Noel S. Weiss
Chu Chen
Ovarian Cancer: Epidemiology and Molecular Endocrinology	398	(15)
Alice S. Whittemore
Valerie McGuire
Testicular Cancer: Epidemiology and Molecular Endocrinology	413	(24)
Anthony J. Swerdlow
Index	437