Human Experimentation and Research

by Tomossy, George F.; Weisstub, David N.

• ISBN13: 9780754622260
• ISBN10: 0754622266
• Format: Hardcover
• Copyright: 2003-12-01
• Publisher: Ashgate Pub Ltd

Summary

As new medical technologies and treatments develop with increasing momentum, the legal and ethical implications of research involving human participants are being called into question as never before. Human Experimentation and Research explores the philosophical foundations of research ethics, ongoing regulatory dilemmas, and future challenges raised by the rapid globalisation and corporatisation of the research endeavour. This volume brings together some of the most significant published essays in the field. The editors also provide an informative introduction, summarizing the area and the relevance of the articles chosen.

Table of Contents

Acknowledgements	ix
Series Preface	xii
Introduction: Human Research Ethics	xv
PART I THE HISTORICALAND PHILOSOPHICAL FOUNDATIONS
1 Hans Jonas (1969), 'Philosophical Reflections on Experimenting with Human Subjects', Daedalus, 98, pp. 219-47.	3	(30)
2 Ruth Macklin and Susan Sherwin (1975), 'Experimenting on Human Subjects: Philosophical Perspectives', Case Western Reserve Law Review, 25, pp. 434-71.	33	(38)
3 Eric M. Meslin, Heather J. Sutherland, James V. Lavery and James E. Till (1995),. 'Principlism and the Ethical Appraisal of Clinical Trials', Bioethics, 9, pp. 399-418.	71	(20)
4 David J. Rothman (1998), 'The Nuremberg Code in Light of Previous Principles and Practices in Human Experimentation', in Ulrich Tröhler and Stella Reiter-Theil in cooperation with Eckhard Herych (eds), Ethics Codes in Medicine: Foundations and Achievements of Codification since 1947, Ashgate: Aldershot, pp. 50-59.	91	(10)
5 James F. Childress (2000), 'Nuremberg's Legacy: Some Ethical Reflections', Perspectives in Biology and Medicine, 43, pp. 347-61.	101	(16)
6 Allen Buchanan (1996), 'The Controversy over Retrospective Moral Judgment', Kennedy Institute of Ethics Journal, 6, pp. 245-50.	117	(6)
7 Tom L. Beauchamp (1996), 'Looking Back and Judging Our Predecessors', Kennedy Institute of Ethics Journal, 6, pp. 251-70.	123	(20)
8 Arthur L. Caplan (1992), 'When Evil Intrudes', Hastings Center Report, 22, pp. 29-32.	143	(4)
9 Sissela Bok (1995), 'Shading the Truth in Seeking Informed Consent for Research Purposes', Kennedy Institute of Ethics Journal, 5, pp. 1-17.	147	(18)
10 Nancy E. Kass, Jeremy Sugarman, Ruth Faden and Monica Schoch-Spana (1996), 'Trust: The Fragile Foundation of Contemporary Biomedical Research', Hastings Center Report, 26, pp. 25-29.	165	(6)
11 George J. Annas (1996), 'Questing for Grails: Duplicity, Betrayal and Self Deception in Postmodern Medical Research', Journal of Contemporary Health Law and Policy, 12, pp. 297-324.	171	(28)
12 David N. Weisstub (1996), 'Roles and Fictions in Clinical and Research Ethics', Health Law Journal, 4, pp. 259-82.	199	(26)
PART II PROTECTING HUMAN SUBJECTS
13 Jay Katz (1993), 'Human Experimentation and Human Rights', Saint Louis University Law Journal, 38, pp. 7-54.	225	(48)
14 Paul R. Benson (1989), 'The Social Control of Human Biomedical Research: An Overview and Review of the Literature', Social Science and Medicine, 29, pp. 1-12.	273	(12)
15 Jonathan D. Moreno (2001), 'Goodbye to All That: The End of Moderate Protectionism in Human Subjects Research', Hastings Center Report, 31, pp. 9-17.	285	(10)
16 Alexander Morgan Capron (1999), 'Is National, Independent Oversight Needed for the Protection of Human Subjects?', Accountability in Research, 7, pp. 283-92.	295	(10)
17 Anna C. Mastroianni (1999), 'National, Independent Oversight: Reinforcing the Safety Net for Human Subjects Research', Accountability in Research, 7, pp. 303-309.	305	(8)
18 Marshall B. Kapp (2002), 'Regulating Research for the Decisionally Impaired: Implications for Mental Health Professionals', Journal of Clinical Geropsychology, 8, pp. 35-51.	313	(18)
19 Robert Michels (1999), 'Are Research Ethics Bad for Our Mental Health?', New England Journal of Medicine, 340, pp. 1427-30.	331	(4)
20 George F. Tomossy and David N. Weisstub (1997), 'The Reform of Adult Guardianship Laws: The Case of Non-Therapeutic Experimentation', International Journal of Law and Psychiatry, 20, pp. 113-39.	335	(30)
PART III RISK AND RESPONSIBILITY
21 Charles Weijer (2000), 'The Ethical Analysis of Risk', Journal of Law, Medicine and Ethics, 28, pp. 344-61.	365	(18)
22 Nancy M.P. King (2000), 'Defining and Describing Benefit Appropriately in Clinical Trials', Journal of Law, Medicine and Ethics, 28, pp. 332-43.	383	(12)
23 David Wendler (2002), 'What Research with Stored Samples Teaches us about Research with Human Subjects', Bioethics, 16, pp. 33-54.	395	(22)
24 Robert J. Levine (1988), 'Uncertainty in Clinical Research', Law, Medicine and Health Care, 16, pp. 174-82.	417	(10)
25 Benjamin Freedman (1987), 'Equipoise and the Ethics of Clinical Research', New England Journal of Medicine, 317, pp. 141-115.	427	(6)
26 Richard Ashcroft (1999), 'Equipoise, Knowledge and Ethics in Clinical Research and Practice', Bioethics, 13, pp. 314-26.	433	(14)
27 S. Senn (2002), 'Ethical Considerations Concerning Treatment Allocation in Drug Development Trials', Statistical Methods in Medical Research, 11, pp. 403-11.	447	(10)
28 Baruch A. Brody (1997), 'When are Placebo-Controlled Trials No Longer Appropriate?', Control Clinical Trials, 18, pp. 602-12.	457	(14)
PART IV GLOBALIZATION AND CORPORATION- TRUST AND PARTICIPATION
29 Ruth Macklin (1999), 'International Research: Ethical imperialism or Ethical Pluralism?, Accountability in Research, 7, pp. 59-83.	471	(26)
30 Marcia Angell (2000), 'Is Academic Medicine for sale?', New England Journal of Medicine, 342, pp. 1516-18.	497	(4)
31 James T. Rule and Adil E. Shamoo (1997), 'Ethical Issues in Research Relationships between Universities and Industry', Accountability in Research, 5, pp. 239-49.	501	(12)
32 Thomas Bodenheimer (2000), 'Uneasy Alliance: Clinical Investigators and the Pharmaceutical Industry', New England Journal of Medicine, 342, pp. 1539-44.	513	(6)
33 Trudo Lemmens and Benjamin Freedman (2000), 'Ethics Review for Sale? Conflict of Interest and Commercial Research Review Boards', Milbank Quarterly Review, 78, pp. 547-84.	519	(38)
34 Jesse A. Goldner (2000), 'Dealing with Conflicts of Interest in Biomedical Research: IRB Oversight as the Next Best Solution to the Abolitionist Approach', Journal of Law, Medicine and Ethics, 28, pp. 379-404.	557	(26)
35 Mark Yarborough and Richard R. Sharp (2002), 'Restoring and Preserving Trust in Biomedical Research', Academic Medicine, 77, pp. 8-14.	583	(8)
36 David B. Resnik (1999), 'Privatized Biomedical Research, Public Fears, and the Hazards of Government Regulation: Lessons from Stem Cell Research', Health Care Analysis, 7, pp. 273-87.	591	(16)
Name index	607