Human Genome Epidemiology A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease

by Khoury, Muin J.; Little, Julian; Burke, Wylie

• ISBN13: 9780195146745
• ISBN10: 0195146743
• Format: Hardcover
• Copyright: 2003-10-23
• Publisher: Oxford University Press

Summary

Advances in genomics are expected to play a central role in medicine and public health in the future by providing a genetic basis for disease prediction and prevention. The transplantation of human gene discoveries into meaningful actions to improve health and prevent disease depends onscientific information from multiple disciplines, including epidemiology. This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genometechnology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches are then illustrated with several disease-specific case studies. The book provides a scientificfoundation that will help researchers, policy makers, and practitioners integrate genomics into medical and public health practice.

Table of Contents

Contributors	p. xv
Fundamentals
Human Genome Epidemiology: Scope and Strategies	p. 3
Emerging Genomic Technologies and Analytic Methods for Population- and Clinic-Based Research	p. 17
Approaches to Quantify the Genetic Component of and Identify Genes for Complex Traits	p. 38
Ethical, Legal, and Social Issues in the Design and Conduct of Human Genome Epidemiology Studies	p. 58
Methods and Approaches I: Assessing Disease Associations and Interactions
Assessing Genotypes in Human Genome Epidemiology Studies	p. 79
Statistical Issues in the Design and Analysis of Gene-Disease Association Studies	p. 92
Facing the Challenge of Complex Genotypes and Gene-Environment Interaction: The Basic Epidemiologic Units in Case-Control and Case-Only Designs	p. 111
Inference Issues in Cohort and Case-Control Studies of Genetic Effects and Gene-Environment Interactions	p. 127
Applications of Human Genome Epidemiology to Environmental Health	p. 145
Reporting and Review of Human Genome Epidemiology Studies	p. 168
Methods and Approaches II: Assessing Genetic Tests for Disease Prevention
Epidemiologic Approach to Genetic Tests: Population-Based Data for Preventive Medicine	p. 195
Genetic Tests in Populations: An Evidence-Based Approach	p. 207
ACCE: A Model Process for Evaluating Data on Emerging Genetic Tests	p. 217
The Interface between Epidemiology and Pharmacogenomics	p. 234
Integrating Genetics into Randomized Controlled Trials	p. 247
Developing Guidelines for the Clinical Use of Genetic Tests: A U.S. Perspective	p. 264
Using Human Genome Epidemiologic Evidence in Developing Genetics Services: The U.K. Experience	p. 283
Case Studies: Using Human Genome Epidemiology Information to Improve Health
Paraoxonase Polymorphisms and Susceptibility to Organophosphate Pesticides	p. 305
Factor V Leiden, Oral Contraceptives, and Deep Vein Thrombosis	p. 322
Methylenetetrahydrofolate Reductase Gene (MTHFR), Folate, and Colorectal Neoplasia	p. 333
Apolipoprotein E and Alzheimer Disease	p. 365
Immunogenetic Factors in Chronic Beryllium Disease	p. 383
Fragile X Syndrome: From Gene Identification to Clinical Diagnosis and Population Screening	p. 402
The Connexin Connection: From Epidemiology to Clinical Practice	p. 423
Genetic and Environmental Factors in Cardiovascular Disease	p. 436
BRCA1/2 and the Prevention of Breast Cancer	p. 451
The Role of Chemokine and Chemokine Receptor Genes in HIV-1 Infection	p. 475
Hereditary Hemochromatosis	p. 495
Genetic Testing of Railroad Track Workers with Carpal Tunnel Syndrome	p. 511
Index	p. 525
Table of Contents provided by Rittenhouse. All Rights Reserved.