Human Growth Hormone

by Smith, Roy G.; Thorner, Michael O.

• ISBN13: 9780896035058
• ISBN10: 0896035050
• Format: Hardcover
• Copyright: 2000-02-01
• Publisher: Humana Pr Inc

Summary

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

Table of Contents

Preface	p. v
Contributors	p. ix
Overview of Human Growth Hormone: Research and Clinical Practice	p. 1
Research	p. 15
GHRP Historical Perspective: Basic and Clinical	p. 17
The Design of Peptidomimetic Growth Hormone Secretagogues	p. 45
Molecular Characterization of Growth Hormone Secretagogue Receptors	p. 69
Central Actions of Peptide and Nonpeptide Growth Hormone Secretagogues	p. 85
Pharmacology of Growth Hormone-Releasing Hormone and Its Peptide Analogs	p. 97
Somatostatin Receptor Subtypes and Regulation of GH Secretion	p. 109
Mathematical Modeling of the GH Release Axis	p. 119
Activation of the Human Growth Hormone Receptor: Structure and Function of the Ligand-Receptor Complex	p. 131
The Central Nervous System as a Direct Target for Growth Hormone Action	p. 145
Clinical Practice	p. 167
Molecular Defects of the Growth Hormone Axis	p. 169
Growth Hormone: Relevance to Pediatrics	p. 191
Growth Hormone Deficiency in Adults: The Rationale for Growth Hormone Replacement	p. 221
Growth Hormone and Osteoporosis	p. 233
Growth Hormone and Syndrome X	p. 247
Interactions Between Growth Hormone Secretion and Sleep	p. 261
Growth Hormone in AIDS	p. 285
Clinical and Physiological Studies with Growth Hormone-Releasing Hormone	p. 297
Clinical Use of Growth Hormone Secretagogues	p. 315
Index	p. 335
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