The Human Pain System: Experimental and Clinical Perspectives

by Frederick A. Lenz , Kenneth L. Casey , Edward G. Jones , William D. Willis

• ISBN13: 9780521114523
• ISBN10: 0521114527
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-02-26
• Publisher: Cambridge University Press

Summary

Pain is a subject of significant scientific and clinical interest. This has resulted both from realistic rodent models, and the publication of imaging, psychological and pharmacological studies in humans. Investigators studying rodents refer to anatomical and physiological studies in non-human primates to make their results relevant to humans. Psychophysical and pharmacological studies in humans are interpreted in terms of anatomical and physiological studies in animals; primarily evidence from rodents and cats. There are significant differences in pain mechanisms between these species and primates. Over 20 years of imaging studies have demonstrated the activation of human cortical and subcortical structures in response to painful stimuli. Interpretation of these results relies upon an understanding of the anatomy and physiology of these structures in primates. Jones, Lenz, Casey and Willis review the anatomy and physiology of nociception in monkeys and humans, and provide a firm basis for interpreting studies in humans.

Table of Contents

Preface	p. vii
Discovery of the anterolateral system and its role as a pain pathway	p. 1
Organization of the central pain pathways	p. 64
Physiology of cells of origin of spinal cord and brainstem projections	p. 196
Physiology of supraspinal pain-related structures	p. 237
Functional brain imaging of acute pain in healthy humans	p. 329
Pain modulatory systems	p. 423
Peripheral and central mechanisms and manifestations of chronic pain and sensitization	p. 453
Functional imaging of chronic pain	p. 540
Functional implications of spinal and forebrain procedures for the treatment of chronic pain	p. 590
Index	p. 624
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