The Hypertrophied Heart

by Takeda, Nobuakira; Nagano, Makoto; Dhalla, Naranjan S.

• ISBN13: 9780792377412
• ISBN10: 0792377419
• Format: Hardcover
• Copyright: 2000-09-30
• Publisher: Kluwer Academic Pub

Summary

Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy. The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.

Table of Contents

Dedication	ix
Preface	xi
Acknowledgment	xiii
A. Mechanisms of Cardiac Hypertrophy
Signal Transduction in the Adapted Heart: Implication of Protein Kinase C-Dependent and -Independent Pathways	3	(14)
John Debarros
Dipak K. Das
Glucose-6-Phosphate Dehydrogenase: A Marker of Cardiac Hypertrophy	17	(14)
Heinz-Gerd Zimmer
Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy	31	(10)
Toru Arino
Ross D. Hannan
Kiyofumi Suzuki
Lawrence I. Rothblum
Mitochondrial Gene Expression in Hypertrophic Cardiac Muscles in Rats	41	(10)
Taro Murakami
Yoshiharu Shimomura
Li Zhihao
Kazuyuki Shimizu
Satoru Sugiyama
SERCA2 and ANF Promoter-Activity Studies in Hypertrophic Cardiomyocytes using Liposome-, Gene Gun- and Adenovirus-Mediated Gene Transfer	51	(16)
Karin Eizema
Han A.A. Van Heugten
Karel Bezstarosti
Marga C. Van Setten
Sonja Schneider-Rasp
Wolfgang C. Poller
Jos M.J. Lamers
Ca2+ Transients, Contractility, and Inotropic Responses in Rabbit Volume-Overloaded Cardiomyocytes	67	(16)
Kiyoharu Sakurai
Hiromi Sugawara
Tomoo Watanabe
Shigekazu Nakada
Hiroyuki Atsumi
Hitonobu Tomoike
Masao Endoh
Responsiveness of Contractile Elements to Muscle Length Change in Hyperthyroid Ferret Myocardium	83	(8)
Tetsuya Ishikawa
Hidetoshi Kajiwara
Seibu Mochizuki
Satoshi Kurihara
Contraction-Dependent Hyprtrophy of Neonatal Rat Ventricular Myocytes: Potential Role for Focal Adhesion Kinase	91	(18)
Diane M. Eble
Ming QI
James Strait
Allen M. Samarel
Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy	109	(14)
Issei Komuro
Possible Roles of the Tenascin Family During Heart Development and Myocardial Tissue Remodeling	123	(8)
Kyoko Imanaka-Yoshida
Kazuto Yokoyama
Teruyo Sakakura
Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling	131	(12)
Shalini Kanekar
Wayne Carver
Thomas K. Borg
Joel Atance
Louis Terracio
Integrin-Dependent and -Independent Signaling During Pressure-Overload Cardiac Hypertrophy	143	(22)
Martin Laser
Toshio Nagai
Vijaykumar S. Kasi
Catalin F. Baicu
Christopher D. Willey
Charlene M. Kerr
Michael R. Zile
George Cooper IV
Dhandapani Kuppuswamy
Role of G Proteins in Hypertension and Hypertrophy	165	(14)
Madhu B. Anand-Srivastava
Francesco Di Fusco
Three-Dimensional Nuclear Size and DNA Content in Hypertensive Heart Disease	179	(8)
Atsushi Takeda
Yuusaku Hayashi
Chihiro Shikata
Yasuyuki Tanaka
Nobuakira Takeda
Age-Related Anisotropic Changes in Cardiocyte Connections in Spontaneously Hypertensive Rats	187	(10)
Makoto Okabe
Keishiro Kawamura
Fumio Terasaki
Tetsuya Hayashi
Yumiko Kanzaki
Haruhiro Toko
Stimulation of Mitogen-Activated Protein Kinases ERK-1 and ERK-2 by H2O2 in Vascular Smooth Muscle Cells	197	(10)
Ashok K. Srivastava
Sanjay K. Pandey
Effects of Renin-Angiotensin System Inhibition on Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats	207	(10)
Naoki Makino
Masahiro Sugano
Sachiyo Taguchi
Adaptation of the Poikilothermic Heart to Catecholamine-Induced Overload	217	(10)
Bohuslav Ostadal
Vaclav Pelouch
Arnost Bass
Pavel Pucelik
Olga Novakova
Angiogenesis and Fibrosis During Right Ventricular Hypertrophy in Human Tetralogy of Fallot	227	(16)
Hari S. Sharma
Erik T.H.F. Peters
Ad J.J.C. Bogers
Molecular Mechanisms of Phenotypic Modulation of Vascular Smooth Muscle Cells	243	(10)
Masahiko Kurabayashi
Ryozo Nagai
B. Cardiac Failure in the Hypertrophied Heart
Protein Kinase C Activation in Cardiac Hypertrophy and Failure	253	(12)
Yasuchika Takeishi
Thunder Jalili
Richard A. Walsh
Angiotensin II and Connective Tissue Homeostasis	265	(14)
Karl T. Weber
Beneficial Effects of Angiotensin Blockade in Heart Failure due to Myocardial Infarction	279	(24)
Naranjan S. Dhalla
Xiaobing Guo
Activated TGFβ Signaling in the Heart After Myocardial Infarction	303	(18)
Jianming Hao
Tracy Scammell-La Fleur
Ian M.C. Dixon
gp 130-Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease	321	(12)
Keiko Yamauchi-Takihara
Keita Kunisada
Yasushi Fujio
Hidemasa Oh
Eiroh Tone
Tadamitsu Kishimoto
Molecular Genetic Aspects of Hypertrophic Cardiomyopathy in the Oriental	333	(12)
Akinori Kimura
Hepatitis C Virus Infection in Hypertrophic or Dilated Cardiomyopathy	345	(10)
Akira Matsumori
Enhancement of Early Diastolic Filling Provoked by Dobutamine Infusion in Dilated Cardiomyopathy	355	(8)
Shingo Kurokawa
Naoki Tokita
Masahiko Moriguchi
Naoto Fukuda
Youji Machida
Tohru Izumi
DNA Fragmentation is a Possible Mechanism for Heart Failure in Cardiomyopathy	363	(12)
Yoshiki Sawa
Satoshi Taketani
Naomasa Kawaguchi
Koji Kagisaki
Shunzo Onishi
Hikaru Matsuda
The Difference in Phosphorylation of Desmin and Myosin Light Chain 2 in the Bio 14.6 Cardiomyopathic Heart	375	(8)
Tajuki Hayakawa
Hiroaki Minami
saiji Masukawa
Tadato Nagane
Katsuro Takeuchi
Osamu Yahara
Kenjiro Kikuchi
Cardiac Remodeling in Cardiomyopathic Hamster Hearts	383	(10)
Hideaki Kawaguchi
Human Myocardial Na, K-ATPase in Remodeling	393	(6)
Keld Kjeldsen
Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes	399	(10)
Uichi Ikeda
Yoshikazu Maeda
Ken-Ichi Oya
Masahisa Shimpo
Shuichi Ueno
Masashi Urabe
Akihiro Kume
John Monahan
Keiya Ozawa
Kazuyuki Shimada
Human Heart Failure: A Mechanistic Assessment of Altered Ventricular Function	409	(14)
Norman R. Alpert
Louis A. Mulieri
The Structural Corrleate of Reduced Cardiac Function in Failing Human Hearts	423	(18)
Sawa Kostin
Diastolic Dysfunction and Diastolic Heart Failure	441	(12)
Kazuhiro Yamamoto
Tohru Masuyama
Yasushi Sakata
Masatsugu Hori
Effects of Melatonin on Cardiac Function and Metabolism in the Ischemic Working Rat Heart	453	(10)
Kenichi Masui
Takeshi Oguchi
Satoshi Kashimoto
Toshiaki Yamaguchi
Teruo Kumazawa
Index	463