Hypoxia : Into the Next Millennium

by Roach, Robert C.; Wagner, Peter D.; Hackett, Peter H.

• ISBN13: 9780306462894
• ISBN10: 0306462893
• Format: Hardcover
• Copyright: 1999-11-01
• Publisher: Springer Verlag

Summary

Hypoxia is a constant threat throughout life. International experts from many different fields, including clinicians, clinical researchers, and basic scientists, have contributed to this volume, presenting state-of-the-art information regarding normal and abnormal (pathophysiological) responses to hypoxia. The topics covered include visitors to high altitude, the latest developments on high-altitude cerebral and pulmonary edema, the brain in hypoxia, high-altitude headache, and similarities between ischemic and hypoxic injury to the brain. In addition topics are covered such as blood-brain barrier in hypoxia, hypoxia interactions with vascular growth, and how humans adjust to extreme hypoxia.

Table of Contents

MOUNTAIN MEDICINE
Herb Hultgren in Peru: What Causes High Altitude Pulmonary Edema?	1	(22)
Drummond Rennie
High Altitude Cerebral Edema and Acute Mountain Sickness: A Pathophysiology Update	23	(24)
Peter H. Hackett
Lung Disease at High Altitude	47	(10)
Robert B. Schoene
Commuting to High Altitude	57	(8)
John B. West
The Pregnant Altitude Visitor	65	(14)
Susan Niermeyer
HIGH ALTITUDE PULMONARY EDEMA
High Altitude Pulmonary Edema: Introduction	79	(2)
Peter Bartsch
Pulmonary Hemodynamics: Implications for High Altitude Pulmonary Edema (HAPE)	81	(12)
J Simon R Gibbs
High-Altitude Pulmonary Edema: From Exaggerated Pulmonary Hypertension to a Defect in Transepithelial Sodium Transport	93	(16)
Urs Scherrer
Claudio Sartori
Mattia Lepori
Yves Allemann
Herve Duplain
Lionel Trueb
Pascal Nicod
FRONTIERS IN NEUROSCIENCE: THE BLOOD-BRAIN BARRIER
Hypoxia and the Blood-Brain Barrier: Introduction	109	(2)
John A. Krasney
What is the Blood-Brain Barrier? A Molecular Perspective	111	(12)
Lester R. Drewes
Mediators of Cerebral Edema	123	(20)
Lothar Schilling
Michael Wahl
FRONTIERS IN NEUROSCIENCE: THE HYPOXIC BRAIN
The Hypoxic Brain: Introduction	143	(2)
Thomas F. Hornbein
High Altitude Headache	145	(10)
Margarita Sanchez del Rio
Michael A. Moskowitz
The Hypoxic Brain: Insights from Ischemia	155	(16)
Konstantin-A. Hossmann
Food for Thought: Altitude versus Normal Brain Function	171	(14)
Marcus E. Raichle
HYPOXIA AND LACTATE: NEW INSIGHTS
Are Arterial, Muscle and Working Limb Lactate Exchange Data Obtained on Men at Altitude Consistent with the Hypothesis of an Intracellular Lactate Shuttle?	185	(20)
George A. Brooks
Role of Pyruvate Dehydrogenase in Lactate Production in Exercising Human Skeletal Muscle	205	(14)
George J. F. Heigenhauser
Michelle L. Parolin
Cross-Species Studies of Glycolytic Function	219	(12)
Peter W. Hochachka
HYPOXIA AND REGULATION OF VASCULAR GROWTH
Hypoxia Induces Cell-Specific Changes in Gene Expression in Vascular Wall Cells: Implications for Pulmonary Hypertension	231	(28)
Kurt R. Stenmark
Maria Frid
Raphael Nemenoff
Edward C. Dempsey
Mita Das
Oxygen and Placental Vascular Development	259	(18)
John CP Kingdom
Peter Kaufmann
Vascular Growth in Hypoxic Skeletal Muscle	277	(10)
Hans Hoppeler
HUMAN PHYSIOLOGY IN EXTREME HYPOXIA
Recent Advances in Human Physiology at Extreme Altitude	287	(10)
John B. West
Operation Everest III (COMEX '97)	297	(22)
Jean-Paul Richalet
Paul Robach
Sebastien Jarrot
Jean-Christophe Schneider
Nicholas P. Mason
Emmanuel Cauchy
Jean-Pierre Herry
Annick Bienvenu
Bernard Gardette
Claude Gortan
Dynamic Cerebral Autoregulation at High Altitude	319	(4)
Benjamin D. Levine
Rong Zhang
Robert C. Roach
Kangchenjunga 1998	323	(12)
Annabel Nickol
David Collier
Why Does the Exercise Cardiac Output Fall During Altitude Residence and is It Important?	335	(16)
John T. Reeves
CHRONIC MOUNTAIN SICKNESS CONSENSUS GROUP
International Consensus Group on Chronic Mountain Sickness	351	(4)
Fabiola Leon-Velarde
John T. Reeves
TRIBUTE TO NIELS LASSEN
Niels Lassen	355	(4)
John W. Severinghaus
ABSTRACTS
Abstracts from the 11th International Hypoxia Symposium	359	(86)
Subject Index	445	(6)
Author Index	451