Hypoxia

by Roach, Robert C.; Wagner, Peter D.; Hackett, Peter H.; International Hypoxia Symposium 2001 (Jasper, Alta.)

• ISBN13: 9780306466960
• ISBN10: 0306466961
• Format: Hardcover
• Copyright: 2002-03-01
• Publisher: Springer Verlag

Summary

Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

Table of Contents

TRIBUTE TO JOHN T. REEVES
John T. Reeves, MD	1	(6)
FROM GENES TO THE BEDSIDE
Genetic lessons from high altitude	7	(6)
Genes, environment, and exercise	13	(8)
Skeletal muscle angiogenesis	21	(18)
Leukocyte-endothelial interactions in environmental hypoxia	39	(22)
TRAINING AT ALTITUDE FOR SEA LEVEL PERFORMANCE
Hypoxia training for sea-level performance	61	(14)
The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise	75	(14)
HIGH ALTITUDE PULMONARY EDEMA
Update: High altitude pulmonary edema	89	(18)
COMPARATIVE BIOLOGY
Phylogenetic comparison and artificial selection	107	(26)
Genetic and environmental adaptation in high altitude natives	133	(20)
Common themes of adaptation to hypoxia	153	(16)
ERYTHROPOIETIN
Biology of erythropoietin	169	(20)
Lessons to better understanding of hypoxia sensing	189	(18)
Erythropoietin use and abuse	207	(18)
MOUNTAIN MEDICINE
Mountaineering in thin air	225	(12)
Weight loss at high altitude	237	(12)
STRESS PROTEINS AND HYPOXIA
The heme oxygenase system and cellular defense mechanisms	249	(24)
Hypoxia-inducible factor in brain	273	(20)
TRANSEPITHELIAL SODIUM TRANSPORT
Proton-gated cation channels - neuronal acid sensors in the central and peripheral nervous system	293	(12)
Structure function relationships of ENaC and its role in sodium handling	305	(10)
Transepithelial sodium and water transport in the lung	315	(24)
ADVANCES IN CARDIORESPIRATORY CONTROL IN HYPOXIA
Is ventilatory acclimatization to hypoxia a phenomenon that arises through mechanisms that have an intrinsic role in the regulation of ventilation at sea level?	339	(10)
Roles of adenosine and nitric oxide in skeletal muscle in acute and chronic hypoxia	349	(16)
The pVHL-HIF-1 system	365	(12)
FRONTIERS IN HYPOXIA RESEARCH
Interval hypoxic training	377	(24)
Gene transfer and metabolic modulators as new therapies for pulmonary hypertension	401	(18)
Chronic mountain sickness	419	(20)
APPENDIX
International Working Group for Chronic Mountain Sickness	439	(2)
Late and Amended Abstracts	441	(2)
Index	443