Hypoxic Pulmonary Vasoconstriction

by Yuan, Jason X. J.

• ISBN13: 9781402078576
• ISBN10: 1402078579
• Format: Hardcover
• Copyright: 2004-05-01
• Publisher: Springer Nature

Summary

Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms will provide a timely and long lasting guide for investigators in the fields of cardiovascular physiology and pathophysiology, pulmonary vascular disease, high-altitude physiology and medicine. In addition, it provides a solid scientific foundation for subsequent applications in clinical practice.The volume is divided into eight sections:- Physiology and Pathophysiology of HPV- Role of Intracellular Ca2+ and Ca2+ sensitivity in HPV- Role of Ion Channels in HPV- Role of the Endothelium in HPV- Mechanisms of Oxygen Sensing in the Pulmonary Vasculature- Oxygen-Sensing Mechanisms in other Organs and Tissues- Pathology and Mechanisms of Hypoxia-Induced Pulmonary Hypertension- Experimental Models for the Study of HPV. State-of-the-art findings relevant to cellular and molecular processes of hypoxic pulmonary vasoconstriction as well as knowledge regarding etiological mechanisms and experimental therapeutics are well covered and complete the overview this volume provides.

Table of Contents

List of Contributors	ix
Preface	xv
I. PHYSIOLOGY AND PATHOPHYSIOLOGY OF HYPOXIC PULMONARY VASOCONSTRICTION
1. Physiological Function of Hypoxic Pulmonary Vasoconstriction
Charles A. Hales	3	(12)
2. Hypoxic Pulmonary Vasoconstriction: Heterogeneity
Christopher A. Dawson	15	(20)
3. The Physics of Hypoxic Pulmonary Hypertension and Its Connection with Gene Actions
Yuan-Cheng Fung and Wei Huang	35	(18)
II. ROLE OF INTRACELLULAR Ca²+ AND Ca²+ SENSITIVITY IN HYPOXIC PULMONARY VASOCONSTRICTION
4. Ca²+ Sparks in Pulmonary Artery Smooth Muscle Cells: Implications for Hypoxic Pulmonary Vasoconstriction
Wei-Min Zhang, Carmelle V. Remillard, and James S.K. Sham	53	(14)
5. Hypoxia-mediated Regulation on Ca²+ Transients in Pulmonary Artery Smooth Muscle Cells
Jean-Pierre Savineau, Sebastien Bonnet, and Roger Marthan	67	(14)
6. Calcium Mobilization by Hypoxia in Pulmonary Artery Smooth Muscle
A. Mark Evans and Michelle Dipp	81	(22)
7. Critical Role of Ca²+ Sensitization in Acute Hypoxic Pulmonary Vasoconstriction
Tom P. Robertson and Ivan F. McMurtry	103	(18)
III. ROLE OF ION CHANNELS IN HYPOXIC PULMONARY VASOCONSTRICTION
8. Regulation of Ion Channels in Pulmonary Artery Smooth Muscle Cells
Sergey V. Smirnov	121	(14)
9. Regulation of O2-sensitive K+ Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction
Rohit Moudgil, Evangelos D. Michelakis, and Stephen L. Archer	135	(30)
10. Hypoxic Regulation of K+ Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells
Hemal Patel, Carmelle V. Remillard, and Jason X.-J. Yuan	165	(34)
11. Transient Receptor Potential Channels and Capacitative Ca²+ Entry in Hypoxic Pulmonary Vasoconstriction
Alison M. Gurney and Lih-Chyuan Ng	199	(18)
IV. ROLE OF ENDOTHELIUM IN HYPOXIC PULMONARY VASOCONSTRICTION
12. Endothelium-dependent Hypoxic Pulmonary Vasoconstriction
Jeremy P.T. Ward and Philip I. Aaronson	217	(16)
V. MECHANISMS OF OXYGEN SENSING IN THE PULMONARY VASCULATURE
13. Chemistry of Oxygen and Its Derivatives in the Lung
Lisa A. Palmer	233	(14)
14. Interaction of Oxidants with Pulmonary Vascular Signaling Systems
Sachin A. Gupte and Michael S. Wolin	247	(16)
15. Mitochondrial Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction
Navdeep S. Chandel	263	(14)
16. Redox Oxygen Sensing in Hypoxic Pulmonary Vasoconstriction
Andrea Olschewski and E. Kenneth Weir	277	(16)
17. Mitochondrial Diversity in the Vasculature: Implications for Vascular Oxygen Sensing
Sean McMurtry and Evangelos D. Michelakis	293	(20)
18. Hypoxia, Cell Metabolism, and cADPR Accumulation
A. Mark Evans	313	(28)
VI. OXYGEN-SENSING MECHANISMS IN OTHER ORGANS AND TISSUES
19. Involvement of Intracellular Reactive Oxygen Species In the Control of Gene Expression by Oxygen
Agnes Görlach, Helmut Acker, and Thomas Kietzmann	341	(20)
20. Oxygen Sensing, Oxygen-sensitive Ion Channels and Mitochondrial Function in Arterial Chemoreceptors
José López-Barneo, Patricia Ortega-Sáenz, Maria Garcia-Fernández, and Ricardo Pardal	361	(14)
21. Oxygen Sensing by Adrenomedullary Chromaffin Cells
Roger J. Thompson and Colin A. Nurse	375	(14)
22. Oxygen-sensitive Ion Channels in Pheochromocytoma (PC12) Cells
Laura Conforti and David E. Millhorn	389	(14)
VII. PATHOLOGY AND MECHANISMS OF HYPOXIA-INDUCED PULMONARY HYPERTENSION
23. Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension
Marlene Rabinovitch	403	(16)
24. Rho/Rho-kinase Signaling in Hypoxic Pulmonary Hypertension
Ivan F. McMurtry, Natalie R. Bauer, Sarah A. Gebb, Karen A. Fagan, Tetsutaro Nagaoka, Masahiko Oka, and Tom P. Robertson	419	(18)
25. Hypoxia-sensitive Transcription Factors and Growth Factors
Ari L. Zaiman and Rubin M. Tuder	437	(12)
26. Heterogeneity in Hypoxia-induced Pulmonary Artery Smooth Muscle Cell Proliferation
Maria G. Frid, Neil J. Davie, and Kurt R. Stenmark	449	(22)
27. Persistent Pulmonary Hypertension of the Newborn: Pathophysiology and Treatment
Steven H. Abman and Robin H. Steinhorn	471	(26)
28. Roles for Vasoconstriction and Gene Expression in Hypoxia-induced Pulmonary Vascular Remodeling
Bernadette Raffestin, Serge Adnot, and Saadia Eddahibi	497	(14)
29. Polyamine Regulation in Hypoxic Pulmonary Arterial Cells
Mark N. Gillespie, Kathryn A. Ziel, Mykhaylo Ruchko, Pavel Babal, and Jack W. Olson	511	(12)
30. Strain Differences of Hypoxia-Induced Pulmonary Hypertension
Mallik R. Karamsetty, James C. Leiter, Lo Chang Ou, Ioana R. Preston, and Nicholas S. Hill	523	(22)
VIII. EXPERIMENTAL MODELS FOR THE STUDY OF HYPOXIC PULMONARY VASOCONSTRICTION
31. Animal and In Vitro Models for Studying Hypoxic Pulmonary Vasoconstriction
Jane A. Madden and John B. Gordon	545	(14)
32. Transgenic and Gene-Targeted Mouse Models in Hypoxic Pulmonary Hypertension Research
Yadong Huang	559	(10)
33. Measurement of Ionic Currents and Intracellular Ca²+ Using Patch Clamp and Fluorescence Microscopy Techniques
Carmelle V. Remillard and Jason X.-J. Yuan	569	(14)
Index	583