Imaging Drug Action in the Brain

by London; Edythe D.

• ISBN13: 9780849388439
• ISBN10: 0849388430
• Format: Hardcover
• Copyright: 1992-12-21
• Publisher: CRC Press

Summary

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail.Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Table of Contents

Preface
Neurobiological Substrates Mediating the Reinforcing Effects of Psychomotor Stimulant and Opiate Drugs	p. 1
Receptor Autoradiography as an Aid in Explaining Drug Action	p. 49
In Vitro Autoradiographic Studies of Drugs Acting at Dopamine Receptor Sites	p. 61
Studies of Benzodiazepine Receptors Using In Vivo Autoradiography	p. 81
CNS Receptors for Opioids	p. 119
Imaging Neuroreceptors to Study Drug Action in Living Human Brain	p. 177
Metabolic Mapping with Deoxyglucose Autoradiography as an Approach for Assessing Drug Action in the Central Nervous System	p. 207
Metabolic Mapping of the Effects of Psychomotor Stimulants	p. 247
Positron Emission Tomographic Studies on the Acute Effects of Psychoactive Drugs on Brain Metabolism and Mood	p. 265
Use of PET to Study Addiction in Humans	p. 281
Inter-Rater Reliability in Positron Emission Tomography Image Analysis	p. 297
Immunohistochemistry as a Strategy for Investigating the Functional Neuroanatomy of Drug Actions in the Brain	p. 317
In Situ Hybridization Histochemistry	p. 337
Identifying and Localizing Gene Expression Important for the Actions of Abused Drugs	p. 379
Advanced Electrophysiological Imaging Techniques for Studying Drug Effects	p. 389
Index	p. 405
Table of Contents provided by Blackwell. All Rights Reserved.