Imaging in Drug Discovery And Early Clinical Trials

by Rudin, Markus

• ISBN13: 9783764371579
• ISBN10: 3764371579
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-12-01
• Publisher: BIRKHAUSER BOSTON INC

Summary

In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation. A chapter describes imaging biomarkers, their development, advantages and the potential pitfalls associated with their use. In the translation of imaging tools from animals to man regulatory issues have to be addressed, which are dealt with in a separate section. The monograph provides a comprehensive overview on the role of imaging in drug discovery today and discusses major developments and trends both with regard to technologies and applications.

Table of Contents

Foreword	vii
The drug discovery process	1	(14)
Paul L. Herrling
Imaging modalities: principles and information content	15	(68)
Tobias Schaeffter
Magnetic resonance and fluorescence based molecular imaging technologies	83	(34)
David Sosnovik and Ralph Weissleder
Studying molecular and cellular processes in the intact organism	117	(34)
Olivier Gheysens and Sanjiv S. Gambhir
Disease phenotyping: structural and functional readouts	151	(34)
R. Mark Henkelman, X. Josette Chen and John G. Sled
Evaluation of drug candidates: efficacy readouts during lead optimization	185	(72)
Markus Rudin, Nicolau Beckmann and Martin Rausch
Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities	257	(22)
Mark W. Tengowski and John J. Kotyk
Pharmacokinetic studies with PET	279	(40)
Mats Bergström and Bengt Långström
Imaging biomarkers predictive of disease/therapy outcome: ischemic stroke and drug development	319	(38)
Janet C. Miller and A. Gregory Sorensen
Clinical drug evaluation using imaging readouts: regulatory perspectives	357	(28)
David S. Lester
Index	385