Immune Dysfunction and Immunotherapy in Heart Disease

by Editor: Ronald Ross Watson (Professor of Public Health, School of Medicine, University of Arizona, Tuscon, ); Editor: Douglas Larson

• ISBN13: 9780470766514
• ISBN10: 0470766514
• Format: eBook
• Copyright: 2008-06-01
• Publisher: Wiley-Blackwell

Summary

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs Immune Dysfunction Leading to Heart Disease: Induction by PathogensBoth researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Table of Contents

Contributors

Preface

About the Editors

Immune dysfunction leading to heart disease: induction by physiological changes

Immunosuppression by ultraviolet light-B radiation: amediator of cardiac remodeling

Immune mechanisms in pediatric cardiovascular disease

Heart failureûrole of autoimmunity

Immune basis of hypertension in humans

Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling

T helper 2 cell cytokines in remodeling of aortic wall

Effects of TNF- on cardiac function

Immunosuppression in promotion of cardiac

McManus & Ismail Laher

Immunotherapy for left ventricular dysfunction after heart transplantation

Immune dysfunction promoting CVD: induction by transplantation drugs

Immunomodulating therapy in chronic heart failure

Statins in atherosclerosis: role of immune regulation

ACE inhibitors as immunomodulators treatment of cardiovascular disease

Treatment of heart failure by anticytokine therapies

Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs

Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome

Cytokines and T cell-mediated responses in autoimmune myocarditis

Drugs of abuse: accentuation of immunomodulation of viral myocarditis

Immune dysfunction leading to heart disease: induction by pathogens

Osteopontin: the link between the immune system and cardiac remodeling

Inflammatory immune activation in heart failure patients: therapeutic implications

Role of innate immune dysregulation in diabetic heart failure

Tolerance in heart transplantation: current and future role

Neutralization of Th2 cytokines in therapy of cardiovascular pathology

Anti-inflammatory immune therapy in heart disease

Cholesterol, interleukin-6 inflammation, and atherosclerosisùrole of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging

Autoimmune myocarditis: treatment with anti-T-cell antibodies

Immunosuppressive therapy to counter cardiac allograft vasculopathy

Role of oral pathogens in the pathogenesis of coronary heart disease

Myocardial regenerative potential by stem cell transplant

Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases

Index

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