Immunological Aspects of the Vascular Endothelium

by Edited by Caroline O. S. Savage , Jeremy D. Pearson

• ISBN13: 9780521184311
• ISBN10: 0521184312
• Edition: 1st
• Format: Paperback
• Copyright: 2011-02-17
• Publisher: Cambridge University Press

Summary

Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation.

Table of Contents

New concepts of mechanisms in autoimmunity

Regulation of endothelial cell function by cytokines

Interactions between granulocytes and endothelium

The regulation of lymphocyte migration by vascular endothelium and its role in the immune response

The role of the vascular endothelium in immunologically-mediated neurological diseases

The role of the endothelium in systemic lupus erythematosus and Sjögren's syndrome

The role of the endothelium in rheumatoid arthritis and scleroderma

The role of the endothelium in systemic vasculitis

Endothelial involvement in childhood Kawasaki disease

The role of the endothelium in thrombotic thrombocytopaenic purpura and haemolytic uraemic sydrome

The immunological role of the endothelium in organ transplantation

Index

Table of Contents provided by Publisher. All Rights Reserved.