Immunology of Fungal Infections

by Brown, Gordon D.; Netea, Mihai G.

• ISBN13: 9781402054914
• ISBN10: 1402054912
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-05-04
• Publisher: Springer Verlag

Summary

The immunology of fungal infections is a comprehensive text covering all aspects of the immunology of infection with these pathogens. In addition to established knowledge, this book covers recent developments in the innate and adaptive immunological mechanisms involved in the host response to fungal infection. The volume is divided into a number of sections, which provides an immunological perspective on the cells, soluble factors and receptors involved in recognising and combating infections with these organisms. Further sections provide detailed descriptions of immunity to specific fungal pathogens, immune-escape mechanisms used by fungi and immune-based therapeutic strategies. This book would be a valuable resource for those interested in fungal immunology particularly, students, specialists, teachers, researchers and clinicians.

Table of Contents

Preface	p. vii
Color Plates	p. ix
Cells
Macrophages	p. 3
Dendritic Cells	p. 27
The Neutrophil	p. 51
Lymphocytes	p. 75
Other Cells: The Role of Non-Neutrophilic Granulocytes, NK and NKT Cells in Fungal Immunology	p. 99
Genes and Gene Pathways in Candida Infection	p. 131
Soluble Factors
Collectins and Pentraxins	p. 151
Complement in Fungal Infections and Complement Evasion Strategies	p. 177
Cytokines	p. 201
Antibodies	p. 235
Non-Opsonic Fungal Receptors
Recognition of Fungal Pathogens by Toll-Like Receptors	p. 259
Fungal [beta]-Glucans and their Receptors	p. 273
Detection of Fungi by Mannose-Based Recognition Receptors	p. 293
Immunity to Specific Pathogens
Pneumocystis	p. 311
Interactions of Aspergillus Fumigatus With its Host During Invasive Pulmonary Infections	p. 331
Candida	p. 359
Immunology of Infections with Cryptococcus Neoformans	p. 381
Histoplasma Capsulatum	p. 407
Fungal Immune Evasion Mechanisms
Escape Mechanisms from the Immune Response	p. 427
Immune-Based Therapeutic Strategies
Cytokine Treatment of Fungal Infections	p. 443
Fungal Vaccines and Vaccination: Problems and Perspectives	p. 463
Index	p. 487
Table of Contents provided by Ingram. All Rights Reserved.