Immunology, Phenotype First

by Beutler, Bruce

• ISBN13: 9783540752028
• ISBN10: 3540752021
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-09-03
• Publisher: Springer Verlag

Summary

This monograph deals with the impact of classical genetics in immunology, providing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who don't fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. 'œWhy bother with classical genetics,' they may ask. 'œWon't all genes be knocked out soon anyway?' Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. 'œWhat has C. elegans to do with me?' they may ask. 'œIt doesn't even have lymphocytes.' They may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind.

Table of Contents

Immunodeficiency
The Forward Genetic Dissection of Afferent Innate Immunity	p. 3
Genetic Analysis of Resistance to Infections in Mice: A/J meets C57BL/6J	p. 27
Host Defenses Against Human Papillomaviruses: Lessons from Epidermodysplasia Verruciformis	p. 59
Innate Resistance to Flavivirus Infections and the Functions of 2'-5' Oligoadenylate Synthetases	p. 85
Cmv1 and Natural Killer Cell Responses to Murine Cytomegalovirus Infection	p. 101
Genetic Dissection of Host Resistance to Mycobacterium tuberculosis: The sst1 Locus and the Ipr1 Gene	p. 123
Self-Reactivity
Scurfy, the Foxp3 Locus, and the Molecular Basis of Peripheral Tolerance	p. 151
Fevers, Genes, and Innate Immunity	p. 169
Itchy Mice: The Identification of a New Pathway for the Development of Autoimmunity	p. 185
TIM Gene Family and Their Role in Atopic Diseases	p. 201
Index	p. 217
Table of Contents provided by Ingram. All Rights Reserved.