Immunopharmacology of Free Radical Species

by Blake, David R.; Winyard, Paul G.

• ISBN13: 9780121035204
• ISBN10: 0121035204
• Format: Hardcover
• Copyright: 1995-07-01
• Publisher: Academic Pr

Summary

Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

Table of Contents

Methods for the Detection and Measurement of Reactive Radical Species in vivo and in Vitro

Lipid Peroxidation and Cardiovascular Disease

Free Radicals and Antioxidants in Atherosclerosis

Oxidant Stress and the Heart: Modulation of Ion Transport Mechanisms during Ischaemia and Reperfusion

Free Radicals in Central Nervous System Diseases

Renal Transplantation and Ischaemia-Reperfusion Injury

A Vascular Basis for Free Radical Involvement in Inflammatory Joint Disease

Reactive Oxygen Species in Skin Inflammation

Free Radicals, Inflammation, and Eye Diseases

Free Radicals in Gastrointestinal and Hepatic Disease

Free Radicals, Muscle Fatigue, and Damage

Free Radicals, Oxidative Stress, and Diabetes Mellitus

DNA Damage by Free Radicals: Carcinogenic Implications

Free Radicals in Lung Inflammation and Environmental Exposure to Pollutants

Free Radicals and Liver Injury

The Conioses: Organotypic Inflammatory Oxidative Responses to Environmental Particulate Pollutants

Reactive Oxygen: Recent Therapeutic Intervention Strategies

Glossary

Subject Index

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