Immunosuppressant Analogs in Neuroprotection

by Borlongan, Cesario V.; Isacson, Ole; Sanberg, Paul R.

• ISBN13: 9780896039445
• ISBN10: 0896039447
• Format: Hardcover
• Copyright: 2003-01-01
• Publisher: Humana Pr Inc

Summary

An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction.

Table of Contents

Foreword	vii
Preface	xv
Contributors	xxv
Part I: Immunosuppressants, Neurologic Disorders, and Neuroprotection
Introduction: Immunosuppressants as Neuroprotective Agents	3	(32)
Marcus F. Keep
Hiroyuki Uchino
Eskil Elmer
Part II: Immunosuppressants and Parkinson's Disease
Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism	35	(14)
Norio Ogawa
Ken-ichi Tanaka
Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo	49	(18)
Lauren C. Costantini
Ole Isacson
Effects of Neuroimmunophilin Ligands on Parkinson's Disease and Cognition	67	(26)
Joseph P. Steiner
Douglas T. Ross
Hansjorg Sauer
Theresa Morrow
Gregory S. Hamilton
Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors	93	(12)
Roger F. Castilho
Oskar Hansson
Patrik Brundin
Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson's Disease: The Mitochondrial Permeability Transition Pore Hypothesis	105	(36)
L. V. P. Korlipara
A. H. V. Schapira
Part III: Immunosuppressants and Other Age-Related Disorders
Immunosuppressants and Alzheimer's Disease	141	(18)
Mark P. Mattson
Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington's Disease	159	(18)
Liza Leventhal
Jeffrey H. Kordower
Part IV: Immunosuppressants, Stroke, and Traumatic Brain Injury
Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury	177	(16)
Vladimir Gogvadze
Christoph Richter
Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion	193	(22)
Hideaki Wakita
Hidekazu Tomimoto
Ichiro Akiguchi
Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia	215	(16)
Ken-ichi Tanaka
M. Asanuma
Norio Ogawa
The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506	231	(32)
A. L. McGregor
P. A. Jones
J. F. McCarter
T. E. Allsopp
J. Sharkey
Immunosuppressants in Traumatic Brain Injury	263	(20)
David O. Okonkwo
John T. Povlishock
Part V: Immunosuppressants and Spinal Cord Injury
Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats	283	(16)
Antonio Ibarra
Araceli Diaz-Ruiz
Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord	299	(18)
Guido Palladini
Brunella Caronti
Part VI: Immunosuppressants and Sciatic Nerve Injury
Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor--FKBP52 Complex	317	(12)
Bruce G. Gold
Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves	329	(14)
Joseph P. Steiner
Heather Valentine
Theresa Morrow
Gregory Hamilton
Part VII: Immunosuppressants and Other Disorders of the Central Nervous System
Cyclosporin A Prolongs Survival of SODI Mutant Mice and Implicates Mitochondrial Permeability Transition in Amyotrophic Lateral Sclerosis	343	(18)
Marcus F. Keep
Keith S. K. Fong
Katalin Csiszar
Eskil Elmer
Psychological Effects of Cyclosporin A	361	(14)
Shigeru Watanabe
Index	375