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Impact of Engineered Nanomaterials in Genomics and Epigenomics

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2023-05-15
  • Publisher: Wiley
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Supplemental Materials

What is included with this book?


Impact of Engineered Nanomaterials in Genomics and Epigenomics

Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level

Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies.

Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field.

Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as:

  • Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism
  • Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics
  • Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity
  • Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure
  • Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses

This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.

Author Biography

Saura C. Sahu, PhD, is a former Research Chemist with the Division of Toxicology at the Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition at the United States Food and Drug Administration.

Table of Contents


List of Contributors xv

Preface xix

Acknowledgments xxi

1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1

Saura C. Sahu Contents

Nanotechnology: A Technological Advancement of the Twenty-First Century 1

Genomics and Epigenomics 1

Beneficial Impacts of Engineered Nanomaterials on Human Life 2

Potential Adverse Health Effects of Engineered Nanomaterials 2

Conclusions 3

References 3

2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5

Kamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil

Introduction 5

Classification of NMs 6

Absorption and Distribution of NMs 6

Major Adverse Effects of NMs 8

Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10

Epigenetic Mechanisms and the Effect of NMs 11

DNA Methylation 12

Genetic and Genomic Effects of NMs 20

Conclusion 25

References 26

3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41

Rais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil

Introduction 41

Toxic Effects of EDCs on Wildlife and Humans 47

Effects During Development 48

Delayed Effects 48

Transgenerational Effects 49

Identification of EDC: Methods 49

Genetic Pathways 50

Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53

ER-Signaling Pathways 53

Xenoandrogens and Metabolic Syndrome 54

AR Signaling Pathways 54

Mechanism of ED 55

Methylation and Gene Regulation 55

Role of Noncoding RNAs 59

Transgenerational Inheritance of Epigenetics Induced by EDCs 59

Anti-Thyroids 60

Organotin 62

Epigenetic Effects of Organotin 63

TCDD and Related Compounds 63

TCDD and Genetic Response 64

TCDD-Mediated Epigenetic Response 65

Conclusions 65

References 66

4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83

Piyoosh Kumar Babele and Ravi Kant Bhatia

Introduction 83

Fate and Behavior of NPs in Agroecosystem and Soil Environment 85

Uptake and Accumulation of NPs in Plants 87

NPs and Phytotoxicity 88

Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89

NPs and Epigenetic Regulation 91

Conclusion and Perspectives 92

References 93

5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99

Delia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini

Introduction 99

Physicochemical Properties of NMs and Toxicity 100

Mechanism of NM Genotoxicity 101

Epigenetic Effects of Nanomaterials 102

Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104

Graphene-Based NMs 120

Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123

Studies on Workers – Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127

Conclusions 132

References 132

6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145

Carlos Wells, Marta Pogribna, Beverly Lyn-Cook, and George Hammons

Introduction 145

Cellular Uptake and Biodistribution 147

DNA Methylation and TiO2 Nanoparticles 151

Histone Modifications and TiO2 Nanoparticles 157

MicroRNAs and TiO2 Nanoparticles 161

Risk Assessment 167

Conclusion 173

Disclaimer 174

References 174

7 Toxicogenomics of Multi-Walled Carbon Nanotubes 187

Pius Joseph

Introduction 187

MWCNTs 188

Lung Injury 190

Inflammation 190

Oxidative Stress 192

Fibrosis 193

Mesothelioma 195

Lung Cancer 196

Genotoxicity 197

Toxicogenomics of ENMs 198

Transcriptomics – Technical Aspects 199

Toxicogenomics of MWCNTs – Animal Studies 201

Toxicogenomics of MWCNT – Human Studies 206

Disclaimer 207

References 207

8 Nano-Engineering in Traumatic Brain Injury 217

Najlaa Al-Thani, Mohammad Z. Haider , Maryam Al-Mansoob, Stuti Patel, Salma M.S. Ahmad, Firas Kobeissy, and Abdullah Shaito

Introduction 217

Nanoparticles in the Treatment of TBI 218

Conclusion 222

References 223

9 Application of Nanoemulsions in Food Industries: Recent Progress, Challenges, and Opportunities 229

Ramesh Chaudhari, Vishva Patel, and Ashutosh Kumar

Introduction 229

Components of Nanoemulsions 231

Approaches for Nanoemulsion Production 232

Applications of Food-Grade Nanoemulsions 235

Comparison of Nanoemulsion from Conventional Methods 241

Problems and Probable Solutions of Nanoemulsions 242

Future Trends and Challenges 243

Regulations and Safety Aspects 243

Conclusion 244

Conflict of Interest 245

Acknowledgments 245

References 245

10 Adverse Epigenetic Effects of Environmental Engineered Nanoparticles as Drug Carriers 251

Yingxue Zhang, Eid Alshammari, Nouran Yonis, and Zhe Yang

Introduction 251

ENP-Based Drug-Delivery Systems 252

Adverse Epigenetic Effects of ENPs 257

ENP-Induced Epigenetic Toxicity Likely Mediated by ROS 269

Conclusion 271

References 271

11 Engineered Nanoparticles Adversely Impact Glucose Energy Metabolism 283

Yingxue Zhang, Alexander Yang, and Zhe Yang

Introduction 283

Biological Toxicity of Engineered Nanoparticles 284

Engineered Nanoparticles Alter Glucose Metabolism 285

Engineered Nanoparticles Alter TCA Cycle 288

Engineered Nanoparticles Alter Oxidative Phosphorylation 289

Conclusion 291

References 291

12 Artificial Intelligence and Machine Learning of Single-Cell Transcriptomics of Engineered Nanoparticles 295

Alexander Yang, Yingxue Zhang, and Zhe Yang

Introduction 295

Impact of Nanoparticles on Single-Cell Transcriptomics and Response Heterogeneity 297

AI and ML in scRNA-Seq Data Analysis 301

Determining Cell Differentiation and Lineage Based on Single-Cell Entropy 303

Conclusion 304

References 305

13 Toxicogenomics and Toxicological Mechanisms of Engineered Nanomaterials 309

Eid Alshammari, Yingxue Zhang, Alexander Yang, and Zhe Yang

Introduction 309

Genomic Responses to ENMs 310

Transcriptomic Responses to ENMs 313

Conclusion 314

References 315

14 Carbon Nanotubes Alter Metabolomics Pathways Leading to Broad Ecological Toxicity 319

Nouran Yonis, Eid Alshammari, and Zhe Yang

Introduction 319

Biomedical Application and Toxicity of Carbon Nanotubes 321

Metabolomics Toxicity of Carbon Nanotubes 323

Conclusion 326

References 326

15 Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry-Based MultiOmics Approaches 331

Nicholas Day, Tong Zhang, Matthew J. Gaffrey, Brian D. Thrall, and Wei-Jun Qian

Introduction 331

Applications of MS for the Measurements of Proteins, PTMs, Lipids, and Metabolites 332

Multiomics Investigation of ENM Exposure to Microorganisms 335

Multiomics Investigation of ENM Exposure Using In Vitro Cell Culture Models 337

Multiomics Studies Reveal Organ-Specific Toxicity at the Organismal Level 340

Conclusions and Perspectives 344

Acknowledgments 347

Compliance with Ethical Standards 347

References 347

16 Current Scenario and Future Trends of Plant Nano-Interaction to Mitigate Abiotic Stresses: A Review 355

Farhat Yasmeen, Ghazala Mustafa, Hafiz Muhammad Jhanzab, and Setsuko Komatsu

Abbreviations 355

Introduction 355

Synthesis of Nanoparticles 356

Morphophysiological Effects of Nanoparticles on Plant 364

Molecular Mechanism Altered by Nanoparticles 370

Nanoparticles Interaction with Plants 374

Conclusion and Future Prospects 375

References 376

17 Latest Insights on Genomic and Epigenomic Mechanisms of Nanotoxicity 397

Vratko Himič, Nikolaos Syrmos, Gianfranco K.I. Ligarotti, and Mario Ganau

Introduction 397

Mechanisms of Genotoxicity 397

Genomic Consequences of ENM Exposure 400

A Primer on Epigenetic Processes 403

Epigenomic Consequences of ENM Exposure 404

Importance of Properties of ENMs 409

Future Perspectives 411

References 411

Index 419

Supplemental Materials

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