Infectious Disease Pathology Clinical Cases

by Woods, Gail L.; Schnadig, Vicki J.; Walker, David H.; Winn, Washington C.

• ISBN13: 9780750696739
• ISBN10: 0750696737
• Format: Hardcover
• Copyright: 1999-11-29
• Publisher: Hodder Education Publishers

Summary

This well-illustrated practical text provides information on the anatomic pathology of infectious diseases. Designed for the non-expert clinician and trainee, the book is organized by organ system and groups the discussion within each chapter according to the predominant type of host inflammatory response. Each chapter consists of a series of case studies that discuss clinical history, pathologic findings, microbiology, and the differential diagnosis. Host reactions discussed in each chapter include minimal reaction, predominance of polymorphonuclear neutrophils, predominance of mononuclear cells, and granulomas. The appendices contain examples of the typical histologic findings associated with viral, fungal, and parasitic infections. The past decade has seen an increase in the number of exotic and unknown organisms and drug-resistant strains of conventional organisms, and it is essential that clinicians stay abreast of recent developments. Infectious Disease Pathology: Clinical Cases is the best tool for assisting physicians in the recognition of the wide range of infectious diseases contracted by patients.

Author Biography

Gail L. Woods, MD is a Professor of Pathology and Director of Clinical Microbiology at the University of Texas Medical Branch in Galveston, TX. Vicki J. Schnadig, MD is an Associate Professor of Pathology and Associate Director of the Division of Cytopathology at the University of Texas Medical Branch in Galveston, TX. David H. Walker, MD is a Professor and Chairman of Pathology at the University of Texas Medical Branch in Galveston, TX. Washington C. Winn, Jr., MD, MBA is a Professor of Pathology at the University of Vermont College of Medicine in Burlington, VT. He is also the Director of Clinical Microbiology Laboratory at Fletcher Allen Health Care in Burlington, VT.

Table of Contents

Preface	xi
Acknowledgments	xiii
Approaches to the Detection of Infectious Agents in Tissue	1	(6)
Viruses	1	(1)
Bacteria	1	(2)
Fungi	3	(1)
Parasites	4	(3)
Infections of the Respiratory Tract	7	(56)
Sinusitis	8	(3)
Lower Respiratory Tract Infection with Wheezing in an Infant	11	(4)
Diffuse Alveolar Damage	15	(2)
Acute Viral Pneumonia with an Intense Neutrophilic Response	17	(2)
Rapidly Progressive Adult Respiratory Distress Syndrome in a Previously Healthy Woman	19	(3)
Viral Pneumonia in the Immunocompromised Host	22	(3)
Acute Suppurative Bronchopneumonia	25	(3)
Acute Bacterial Pneumonia with an Exudate of Polymorphonuclear Neutrophils and Macrophages	28	(3)
Necrotizing Bronchopneumonia	31	(3)
Pneumonia Containing Histiocytic Aggregates	34	(3)
Cavitating Pneumonia with Caseating Granulomas	37	(3)
Diffuse Interstitial Pulmonary Infiltrates with Caseating Granulomas	40	(4)
Pneumonia with Mixed Suppurative and Granulomatous Inflammation	44	(4)
Miliary Lesions in the Immunocompromised Patient	48	(4)
Pulmonary Interstitial Infiltrates in the Immunocompromised Patient	52	(4)
Recurrent Hemoptysis and Radiologic Pulmonary Lesion	56	(2)
Coin Lesion	58	(5)
Infections of the Gastrointestinal Tract	63	(30)
Oropharyngeal Ulcers	65	(2)
Inflammatory Mass of the Jaw with Granules	67	(2)
Esophagitis	69	(3)
Active Chronic Gastritis	72	(2)
Afebrile Subacute Abdominal Distress	74	(2)
Enterocolitis Accompanied by Pulmonary Disease	76	(3)
Enterocolitis in a Patient with Acquired Immunodeficiency Syndrome	79	(2)
Small Intestinal Ulcers with Perforation in a Patient with Acquired Immunodeficiency Syndrome	81	(4)
Enteric Disease with Caseating Granulomas	85	(2)
Enteric Disease with Diffuse Histiocytic Infiltrates	87	(2)
Granulomatous Inflammation of the Mid--Gastrointestinal Tract and Draining Lymph Nodes	89	(4)
Infections of the Liver	93	(30)
Acute Hepatitis	94	(2)
Acute Hepatitis in an Immunosuppressed Patient	96	(2)
Chronic Hepatitis	98	(2)
Fever, Hepatic Injury, and a Fatal Outcome in a Patient in West Africa	100	(2)
Fulminant Hepatic Failure	102	(2)
Granulomatous Hepatitis	104	(3)
Aggregates of Foamy Macrophages	107	(3)
Fever and Hepatitis with Ring Granulomas	110	(2)
Multiple Abscesses of the Liver	112	(2)
Space-Occupying Necrotizing Lesion	114	(2)
Space-Occupying Disease of the Liver Characterized by Multiple Thin-Walled Cysts	116	(3)
Cholangiopathy	119	(4)
Infections of the Skin and Subcutaneous Tissue	123	(34)
Vesicular Rash in an Immunosuppressed Patient	125	(2)
Fever and Maculopapular Rash	127	(2)
Centrifugally Expanding Rash and Systemic Symptoms	129	(2)
Dermal Histiocytic Aggregates	131	(3)
Disseminated Ulceronodular "Rash"	134	(3)
Ulcerative Nodules	137	(5)
Granulomatous Inflammation of the Skin	142	(3)
Chromoblastomycosis	145	(2)
Granulomatous Infection of Soft Tissue	147	(2)
Subcutaneous Abscesses	149	(2)
Multiple Erythematous Cutaneous Papules and Cough in a Febrile Patient with Acquired Immunodeficiency Syndrome	151	(2)
Fever and Gangrene of the Extremities	153	(4)
Infections of the Central Nervous System	157	(38)
Acute Meningitis	158	(2)
Chronic Meningitis	160	(5)
Acute Meningoencephalitis	165	(2)
Hemorrhagic Encephalitis	167	(2)
Confusion, Ataxia, and Pulmonary Infiltrates in a Previously Healthy Man	169	(2)
Fever and Coma During Travel in the Tropics	171	(3)
Progressive Neurologic Disease with Demyelinating Lesions	174	(2)
Insidious Neurologic Disease in a Patient with Human Immunodeficiency Virus Infection	176	(2)
Hemorrhagic Infarction	178	(3)
Intracranial Space-Occupying Lesion in a Previously Healthy Man	181	(2)
Space-Occupying Lesion in a Patient with Acquired Immunodeficiency Syndrome	183	(3)
Necrotizing Mass Lesions in a Human Immunodeficiency Virus--Infected Patient	186	(3)
Cystic Mass Lesion of the Frontal Lobe	189	(2)
Progressive Neurologic Impairment in a Patient with Acquired Immunodeficiency Syndrome	191	(4)
Infections of the Genitourinary System	195	(22)
Fever and Severe Back Pain of Two Weeks' Duration	196	(5)
Genital Ulcers	201	(3)
Abnormal Genital Cytopathology	204	(2)
Premature Rupture of Membranes with Infection of the Amniotic Fluid	206	(2)
Stillborn Infant Secondary to Intrauterine Infection	208	(2)
Nonfunctioning Kidney After Nephrolithiasis and Recurrent Urinary Tract Infections	210	(3)
Difficulty in Urination and an Enlarged, Nodular Prostate Gland	213	(4)
Infections of the Hematopoietic System	217	(82)
Fever and Splenomegaly in a Central American Immigrant	218	(2)
Elderly Asplenic Steroid-Treated Patient with Fever and Thrombocytopenia	220	(2)
Recurrent Episodes of Febrile Flulike Illness	222	(2)
Hydrops Fetalis with Inclusions in Bone Marrow Hematopoietic Cells	224	(3)
Overwhelming Infection with Monocytic Cells Containing Cytoplasmic Inclusions in Bone Marrow	227	(1)
Fever and Pancytopenia in a Previously Healthy Man	228	(1)
Pancytopenia and Multisystem Febrile Illness in a Human Immunodeficiency Virus--Infected Patient	229	(4)
Recurrent Fever and Granulomatous Infection of Hematopoietic Tissue	233	(2)
Spindle-Cell Mass in the Spleen	235	(2)
Lymphadenitis with Necrotizing Granulomas After Cat-Induced Trauma	237	(2)
Lymphadenopathy with Large Aggregates of Histiocytes	239	(3)
Postoperative Illness with Recurrent Cardiorespiratory Manifestations	242	(7)
Appendices
Appendix A: Viral Cytopathic Effects	249	(8)
Appendix B: Appearance of Bacteria in Smears and Tissue	257	(12)
Appendix C: Appearance of Fungi and Algae in Cytologic Preparations and Tissue Sections	269	(14)
Appendix D: Appearance of Parasites in Cytologic Preparations and Tissue Sections	283	(16)
Index	299