Inflammation and Allergy Drug Design

by Izuhara, K.; Holgate, Stephen T.; Wills-Karp, Marsha

• ISBN13: 9781444330144
• ISBN10: 1444330144
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-09-26
• Publisher: Wiley-Blackwell

Summary

This book educates the reader on the molecular and cellular mechanism of allergic diseases in the respiratory tract covering all aspects, from its immunological basis to its application in drug development. In contrast to other books, this book focuses on well-known and newly-emerging cells, cytokins, and mediators involved in the pathogenesis of allergic diseases in the respiratory tract. In particular, this book emphasises the findings of novel drug targets. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development.

Author Biography

Edited by
K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan
Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK
Marsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA

Table of Contents

Contributors	p. vii
Preface	p. xiii
Cells contributing to the pathogenesis of allergic diseases in the respiratory tract
Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells	p. 3
Role of Th2 cells in the allergic diathesis	p. 15
Importance of Th17- and Th1-associated responses for the development of asthma	p. 27
Regulatory T cells	p. 39
A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders	p. 59
Regulatory roles of B cells in allergy and inflammation	p. 67
Mast cells	p. 79
Eosinophils	p. 107
Basophils in inflammation and allergy drug design	p. 123
Epithelial cells	p. 139
Fibroblasts	p. 149
Airway smooth muscle ceils	p. 163
Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract
Interleukin 4, interleukin 13, and interleukin 9	p. 175
Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor	p. 187
Interleukin 15, interleukin 17, and interleukin 25	p. 197
Thymic stromal lymphopoietin	p. 205
Interleukin 10	p. 215
Tumor necrosis factor alpha	p. 225
Profibrotic and angiogenic factors in asthma	p. 237
Chemokines	p. 253
Epithelial growth factors	p. 263
Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract
Prostanoids	p. 273
Leukotrienes	p. 285
Proteases in allergy	p. 297
Toll-like receptors	p. 307
Index	p. 317
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